This report records and discusses the Third Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE3). The report includes a description of the keynote presentation of the workshop, which served as an overview of sustainable scientific software. It also summarizes a set of lightning talks in which speakers highlighted to-the-point lessons and challenges pertaining to sustaining scientific software. The final and main contribution of the report is a summary of the discussions, future steps, and future organization for a set of self-organized working groups on topics including developing pathways to funding scientific software; constructing useful common metrics for crediting software stakeholders; identifying principles for sustainable software engineering design; reaching out to research software organizations around the world; and building communities for software sustainability. For each group, we include a point of contact and a landing page that can be used by those who want to join that group's future activities. The main challenge left by the workshop is to see if the groups will execute these activities that they have scheduled, and how the WSSSPE community can encourage this to happen.

To develop ampicillin-loaded chitosan nanoparticles by modified ionic gelation method for evaluating their antimicrobial activity onto Escherichia coli. Methods: Ampicillin-loaded chitosan nanoparticles (CHT-NPs) prepared by ionic gelation method with sodium tripolyphosphate as cross-linking agent. Drug release parameters (zeta potential, particle size, entrapment efficiency, and in vitro drug release) were assessed in relation to CHT-NP antimicrobial profile on E. coli. Antibacterial properties of CHT-NP formulation with ampicillin were found better than mere ampicillin without CHT-NPs. Results: SEM, AFM images revealed dimensions of CHT-NPs with irregularity in shape/ size. Optimized concentrations of chitosan 0.5% w/v with three different ratios (0.05% to 0.3% w/v) of TPP proved optimal for the evaluation of antibacterial profile of CHT-NPs. In vitro ampicillin-loaded CHT-NP delivery studies revealed an initial burst followed by slow sustained drug release, demonstrating superior antimicrobial activity than plain ampicillin, due to the synergistic effect of chitosan and ampicillin. Conclusion: Chitosan content and cross-linking agent concentrations are control factors in synthesis of the optimized CHT-NP formulation. CHT-NPs with ampicillin cargo capably sustained ampicillin delivery due to NP size and increased surface charge, resulting in efficient growth inhibition in assays with E. coli.

El presente trabajo utiliza el modelo de Suzuki (Suzuki, 1983) para simular la caída de ceniza volcánica en la versión TEPHRA (Connors, 1991). El programa TEPHRA modificado es sometido a prueba al simular exitosamente la distribución de ceniza de los eventos eruptivos mejor conocidos en el volcán Irazú, Costa Rica. Adicionalmente, la masa de ceniza acumulada por 52 simulaciones de diseño concuerda satisfactoriamente con la distribución de las isopacas de la ceniza depositada durante el periodo 1963-65 del volcán Irazú y relativamente bien con la distribución de isopacas de la ceniza depositada durante los últimos 2600 años de actividad. Esta situación justifica la aplicación del programa TEPHRA modificado en la elaboración de mapas de amenaza por caída de ceniza para el Volcán Irazú y otros volcanes en los cuales se tenga apropiada información sobre dirección del viento y características eruptivas más probables de presentarse en el volcán.