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Wound healing is a complicated system that necessitates an appropriate environment to aid healing. Wound dressing is among the most important external variables in wound repair. Technology advancements have led to the creation of a variety of dressings that treat various wound types by focusing on the four stages of wound healing. Simplicity of application, sterility, antibacterial, non‐adherent, gaseous exchange, non‐toxicity, and other qualities are necessary for wound dressings. In order to fully regenerate and restore the structure and functionality of the skin, the ideal dressing should address the demands of the wound. So, the kind of wound dressing used is based on the type of injury. This review focuses on the different types of natural polymers such as κ‐carrageenan, chitosan, cellulose, gelatin, collagen, alginate, hyaluronic acid, and silk fibroin used in the development of dressing materials such as hydrogels, nanofibers, sponges, films, and various other types of scaffolds owing to their features, for example, biocompatibility, biodegradability, and similarity to human extracellular matrix (ECM) which aids in the healing process. The commercially available products based on these natural polymers are also discussed in the review. However, the majority of the natural polymer‐based wound dressings still exhibit a number of problems like adherence, opaque, fast degradability, and lack of multifunctionality, thus these need to be addressed. A naturally inspired smart wound dressing is the need of the hour which aids in individual stages of healing by monitoring the multiple wound variables such as pH, temperature, electrical potentials and eases the incorporated drug and biological molecules as per wound healing progress with a variety of delivery systems.

Calcium pectinate (CaP)--the insoluble salt of pectin--can potentially be used as a colon-specific drug delivery system. The use of CaP as a carrier was based on the assumption that, like pectin, it can be decomposed by specific pectinolytic enzymes in the colon but that it retains its integrity in the physiological environment of the small bowel. The biodegradation of the carrier was characterized by monitoring the percent cumulative release of the insoluble drug indomethacin, incorporated into pectin or CaP matrices. Compressed tablets of pectin and indomethacin were analyzed for degradation in the presence of Pectinex 3XL, a typical pectinolytic enzyme mixture, and in the presence of the human colonic bacterium Bacteroides ovatus. The degradation of CaP-indomethacin tablets was assessed in the presence of Pectinex 3XL and in rat cecal contents. The release of indomethacin was significantly increased (end-time percentage cumulative release vs control) in the presence of Pectinex 3XL (89 +/- 20 vs 16 +/- 2 for CaP tablets), Bacteroides ovatus (12 and 22 vs 5.2 for pectin tablets), and rat cecal contents (61 +/- 16 vs 4.9 +/- 1.1 for CaP tablets). The weight loss of tablet mass was significantly higher (end-time dry weight vs control) in the presence of Pectinex 3XL (0 vs 75 +/- 6% of initial weight for CaP tablets). These findings indicate the potential of CaP, compressed into tablets with insoluble drug, to serve as a specific drug delivery system to the colon.

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A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg).