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Summary:Behufs disease is characterized by orogenital ulccrations and ocular lesions, Other features include arthritis, thrombophlebitis, neurological abnormalities and skin lesions. The disease is characterized by a relapsing inflammatory process of unknown aetiology. Lipoprolcin(a) is an LDL-likc particle with a large glycoprotein called apolipoprotein(a) attached to its npolipoprotcin B moiety through one or more clisulphidc bonds. Apolipoprotein(a) is related to plasminogcn from which the cn/yme plasmin, that hydrolyscs fibrin blood clots, is released by tissue plasininogcn activators. The unique structural features of Lp(a) give it the potential for atherogenie and thrombogenic activities. In the present study 35% of patients with /ic j //(.'t'/\s disease were shown to have higher Lp(a) concentrations than the cut-off point (0.30 g/l) for atherosclerosis. Plasma Lp(a) concentrations in the remission period were also found 1ο be lower than during the active period in the same patients (23% decreased). Lp(a) showed significant correlations with acute phase rcaclanls such as crythrocyte sedimentation rate, polymorphonuclcar leukocytes and polymoφhonuclear leukocyte elastase activity. Therefore, it was concluded that the fluclations of plasma Lp(a) levels with the activity of disease may be a contributing risk factor in the development of (hrombogcnic complications in patients with Belief $ disease.In conclusion, we suggest that plasma Lp(a) concentrations be determined for patients with Belter* disease, and that patients with high Lp(a) levels be kept under close controls especially during the active period of the disease, and taken into remission as soon as possible.

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Background: Primula vulgaris has been used in traditional treatment, and its biological functions are attributed to its polyphenolics content. Objectives:The aim of this study was to determine the phenolics composition and the antioxidant activity of water extract of P. vulgaris (WEP) and to determine its probable preventive effects against H2O2-induced DNA damage in human fibroblast cells. Methods: The total polyphenolic content (TPC), ferric reducing antioxidant power (FRAP), and radical scavenging activity of WEP were determined using spectrophotometric methods. Phenolic compounds and antigenotoxic effects of WEP were evaluated using HPLC and comet assay, respectively. Results:The TPC and FRAP values of WEP were 15.023 ± 0.84 mg gallic acid and 82.63 ± 0.31 µM trolox per g sample, respectively. ρ-coumaric acid and rutin were detected as major phenolics. Moreover, WEP reduced H2O2-induced DNA damage in a concentration dependent manner in fibroblast cells compared to the positive controls (only 20 µM H2O2 treatment). Conclusions:Primula vulgaris can be used in food, cosmetics, and drug industries because of its antioxidant and antigenotoxic activities.