The Effects of Atorvastatin Therapy on Rheological Characteristics of Erythrocyte Membrane, Serum Lipid Profile and Oxidative Status in Patients with Dyslipidemia

Erythrocyte Membrane Fatty Acid Composition in Premenopausal Patients with Iron Deficiency Anemia

“…The differences in concentrations between the groups were not significant statistically p 0.09 Table 2 . Docosahexaenoic acid concentrations reported in this study were in agreement with some previous reports 13 as well as lower than that reported in other studies 19,22,23,27,29,30 .…”

“…The differences of oleic acid concentrations in between the groups were significant statistically p 0.05 Table 2 . Oleic acid concentrations reported in this study were in agreement 19,20,23,26 , as well as higher 22,24,27 and lower 25 than those reported in some previous studies. Linoleic acid C18:2 concentration was found to be 15.29 in the erythrocyte membranes in subjects of the case group and 15.39 in those of the control group.…”

The Effect of Combined Ezetimibe/Atorvastatin Therapy vs. Atorvastatin Monotherapy on the Erythrocyte Membrane Structure in Patients with Coronary Artery Disease: A Pilot Study

“…Marinez-Sanches et al [18] note increased concentrations of MDA (malondialdehyde), the main end-product of lipid peroxidation, in patients with hypercholesterolemia, while Walter et al [19] demonstrate a correlation between the concentration of TBARS and the incidence of cardiovascular events. Uydu et al [20] report similar results following the use of atorvastatin in patients with hypercholesterolemia or hyperlipidemia: a decrease in the concentration of TBARS was seen after 12-week therapy at a dose of 10 mg/day.…”

Influence of Simvastatin Chronotherapy on Erythrocytes Nitric oxide Synthase Activity

“…Under HC condition, statins persevered structural and functional features of erythrocyte membranes and oxidant/antioxidant balance. This may attributed to statins therapy which (Tziakas et al, 2009) decreases cellular cholesterol inclusion (Mason et al, 2004;Forsyth et al, 2012;Uydu et al, 2012). Also, statins scavenge free radicals, preserve NOS cofactors, prevent NOS uncoupling and enhance NOS activity (Ozuyaman et al, 2008;Harisa et al, 2012;Li and Forstermann, 2013).…”

“…They decreased cholesterol levels, modulate NOS activity and have pleiotropic effects (Mason et al, 2004;Lahera et al, 2007). These effects include regulation of erythrocytes membrane cholesterol homeostasis, rheology and antioxidant capacity (Forsyth et al, 2012;Uydu et al, 2012;Adekunle et al, 2013). Kamal (2011) suggested that evening statin dosing elicit more effective treatment than morning dosing.…”