Introduction: Myocardial infarction without obstructive coronary artery disease (MINOCA) accounts for 5-15% of acute myocardial infarction (MI) cases. Objectives: The purpose of this study is to determine the prevalence of diabetes, hypertension, hyperlipidemia, smoking, and family history of cardiovascular diseases (CVDs) and their association with gender in patients with MINOCA. Patients and Methods: Around 1772 patients entered this cross-sectional study. Prevalence of diabetes, hypertension and hyperlipidemia was significantly higher in women compared to men (P<0.001). Smoking was more common in men than women (P<0.001). Results: Women with MINOCA are more likely to have hypertension, hyperlipidemia and diabetes than men with MINOCA, whereas men are more likely to be smokers. Conclusion: Effective blood pressure control, correction of lipid profile and proper glycemic control can prevent MINOCA and its associated morbidities and mortality, especially in women.

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Background: Alzheimer's disease (AD) is a debilitating neurodegenerative disease. Early diagnosis of AD and its precursor, mild cognitive impairment (MCI), is crucial for timely intervention and management. Magnetic resonance imaging (MRI) radiomics showed a promising result for diagnosing and classifying AD, and MCI from normal subjects. Thus, we aimed to systematically evaluate the diagnostic performance of the MRI radiomics for this task. Methods and materials: This study was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. A comprehensive search of the current literature was conducted using relevant keywords in PubMed/MEDLINE, Embase, Scopus, and Web of Science databases from inception to October 17, 2022. Original studies discussing the diagnostic performance of MRI Radiomics in Alzheimer's disease (AD), and mild cognitive impairment (MCI) diagnosis were included. Method quality was evaluated with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), and the Radiomic Quality Score tool (RQS). Results: We identified 10 studies that met the inclusion criteria, involving a total of 3446 participants. The overall quality of the included studies was moderate to high. The pooled sensitivity and specificity of MRI radiomics for differentiating AD from normal subjects were 0.8822 (95% CI 0.7888-0.9376), and 0.8849 (95% CI 0.7978-0.9374), respectively. The pooled sensitivity and specificity of MRI radiomics for differentiating MCI from normal subjects were 0.7882 (95% CI 0.6272-0.8917) and 0.7736 (95% CI 0.6480-0.8639), respectively. Also, the pooled sensitivity and specificity of MRI radiomics for differentiating AD from MCI were 0.6938 (95% CI 0.6465-0.7374) and 0.8173 (95% CI 0.6117-0.9270), respectively. Conclusion: MRI radiomics has promising diagnostic performance in differentiating AD, MCI, and normal subjects. It can potentially serve as a non-invasive and reliable tool for early diagnosis and classification of AD and MCI. However, further studies with larger sample sizes and more rigorous study designs are warranted to confirm these findings and establish the clinical utility of MRI radiomics in AD and MCI diagnosis.

Introduction: Acute coronary artery syndrome is a term to describe a wide range of diseases associated with a sudden and severe decrease in blood flow to the heart. Objectives: This study aimed to evaluate the variables related to the severity and type of coronary artery involvement in patients with the acute coronary syndrome (ACS). Patients and Methods: This study is a retrospective analytical descriptive study. The statistical population of this study included patients who were admitted to the vascular ward of Shahid Mohammadi hospital in Bandar-Abbas during 2017-2020 with a diagnosis of the ACS and underwent coronary angiography. Results: In the study of the main vessel involvement, left anterior descending artery (LAD) with 38.15% and RCA with 23.97% were the most common vessels involved. The most involved vessels were LAD-right coronary artery (LAD-RCA) (8.61%), left circumflex artery (LCX) (7.95%), obtuse marginal artery (OM) (7.68%) and diagonal arteries (4.77%), respectively. The most common sites of involvement in Chen’s anterior descending vessel were the middle part of LAD (m.LAD), the proximal part of LAD (p.LAD), and then the distal part of LAD (d.LAD), respectively. Most of the places of conflict RCA, precisely similar to LAD, were the middle part of RCA (m.RCA), the proximal part of RCA (p.RCA) and the distal part of RCA (d.RCA). There was a statistically significant relationship between the severity of coronary artery disease (CAD) according to age, gender, diabetes, blood pressure, family history and the number of vessels involved. There was no statistically significant relationship between the severity of coronary artery involvement, smoking and mean body mass index (BMI). Conclusion: As it is shown, our results were quite similar to other studies around the country. Hence, following the nationwide guidelines for treating CVD in this city seems rational and helpful.

IgA vasculitis nephritis (Schönlein-Henoch purpura nephritis) is an autoimmune circumstance characterized by palpable purpura involving the lower limbs, arthralgia, abdominal pain and kidney involvement. It is possible that a cytokine storm following coronavirus disease 2019 (COVID-19) could lead to an immunological dysregulation responsible for IgA vasculitis nephritis in these cases. Reactivation or first onset of IgA vasculitis nephritis is uncommon; however, there have been increasing reports of this disease, as a complication of COVID-19 vaccination. It is possible that COVID-19 mRNA vaccination may trigger several auto-inflammatory and autoimmune cascades. Previous research has shown that Toll-like receptors play a role in the development of IgA vasculitis nephritis. Following injection of a COVID-19 mRNA vaccine, the uptake of double-stranded RNA by-products will trigger Toll-like receptors, leading to a series of intracellular cascades starting an innate immunity-driven process of cell-mediated and humoral- mediated immunity.