Background:High blood pressure (BP) has been known as a major risk factor for many chronic diseases. It should be noted, a psychiatric disorder which is common in the people living modern lifestyle may be one of the leading causes of hypertension, and many people are prescribed antidepressant each year. Hence, the purpose of this study was to evaluate the effect of selective serotonin reuptake inhibitors (SSRIs) and alprazolam which defined as antidepressant on the BP levels, and to compare the BP levels between the group of users and nonusers.Methods:This randomized clinical trial study was conducted at the Nohom Dey Hospital in the Torbat-e Heydarieh, Iran between December 2011 and March 2012. Participants comprised 101 psychiatric patients with hypertension that randomly separated into users and nonusers of antidepressant. The period of intervention lasted for 3 months. The mean of BP calculated by this formula (systolic BP [SBP] +2 diastolic BP [DBP])/3 which was the main outcome of the study.Results:Users of antidepressant drugs did not have any significant changes in BP levels, except in patients who received SSRIs alone, significant improvement was observed in DBP (P = 0.04) and mean of BP (P = 0.03). While, in nonusers of antidepressant, significant development was observed in DBP, and mean of BP. Comparing the users and nonusers did not show any significant differences in SBP, DBP, and Mean of BP; even, when outcomes were adjusted for risk factors and antihypertensive drugs.Conclusions:Three months treatment with SSRIs and alprazolam did not have any effect on lowering BP level in patients with the psychiatric disorder.

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Aim: Evidence indicates there are still conflicts regarding CETP Taq1B polymorphism and coronary artery disease risk factors. Current knowledge about whether dietary patterns can change the relationship of the Taq1B on lipid profile and the severity of coronary arteries stenosis is limited. Present research aimed to investigate this hypothesis. Methods: This cross-sectional study involved 453 male and female participants, with a mean age of 57 years. A validated 178-item food frequency questionnaire ( FFQ ) used to assess dietary usual intake. Dietary patterns extracted through principal component analysis (PCA). Taq1B variant genotyped by the polymerase chain reaction-restriction fragment length polymorphism method. Two-way ANOVA was used to test the interaction between Taq1B polymorphism and dietary patterns. Results: Two dietary patterns were detected: the western dietary pattern (WDP) and the traditional dietary pattern (TDP). The frequency of Taq1B genotypes was 10.4, 72.4, and 17.2% for B1B1, B1B2, and B2B2, respectively. Carriers of the B2 allele who adhered highly to either TDP or WDP had lower levels of TG and a lower ratio of TG to HDL-C. Taq1B had a significant interaction with TDP for modulating TG in both unadjusted and adjusted models (P = 0.04 and P = 0.02, respectively), and also in TG/HDL-C ratio in the adjustment model (P = 0.04). No significant difference or interaction observed in the other variables among Taq1B genotypes and diets. Conclusion: TDP may alter the relationship between CETP Taq1B and TG and TG/HDL among subjects under coronary angiography. Longitudinal and interventional studies suggest for a better understanding of the role of diets and Taq1B variant in cardio-metabolic risk factors.

Background: Several studies have assessed the association of the cholesterol ester transfer protein (CETP) (rs708272) TaqIB gene polymorphism with risk factors of CVDs; however, their results are inconsistent. The current study investigated the relationship between CVD risk factors and the Taq1B variant in a population from Iran that was undergoing coronary angiography. Methods: This cross-sectional study was conducted on 476 subjects aged (30-76) years of both sexes. Genotypes for Taq1B polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using extracted DNA from whole blood. Cardio-metabolic markers were measured by standard protocols. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models. Results: Genotype frequencies of the Taq1B polymorphism were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. No significant association was observed between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (p= 0.64), Syntax score (p = 0.79), systolic blood pressure (p = 0.55), diastolic blood pressure (p = 0.58), waist circumference (p = 0.79). None of the abnormal serum levels were related to genotypes of the rs708272 variant. Results remained not significant after adjusting for confounders. Conclusion: Risk factors for CVDs were not associated with CETP rs708272 polymorphism in our population. Various findings reported in different populations that it suggested more studies in various regions in connection with CETP gene variants which are linked to CVD events.