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Introduction: Stroke is defined by (WHO) World Health Organization as 'a clinical syndrome consisting of rapidly developing clinical signs of focal (or global in case of coma) disturbance of cerebral function lasting more than 24 hour or leading to death with no apparent cause other than a vascular origin.' There are few studies conducted in Indian scenario, which shows the role of serum uric acid in cases of acute ischaemic stroke. So the present study aimed at evaluating role of uric acid in assessing severity of acute ischemic stroke. Material and methods: It was an Analytical, Non interventional Prospective study conducted among 100 cases of acute ischaemic stroke admitted in medicine ward and ICU at Krishna hospital, Karad over the period of 18 months, who fulfilled inclusion criteria were included in our study. Results: In the present study, serum uric acid levels and its distribution was carried out. Mean levels of Serum Uric acid was 4.92 ± 1.89 mg/dl. Maximum value being 8.4 mg/dl and minimum value was 1.2 mg/dl. Conclusion: The severity of acute ischaemic stroke was proved to be directly proportional to the mean serum uric acid levels in the present study.