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Background:Prostate is an important male reproductive system gland and its disorders can affect men's quality of life and health. Prostatitis, benign prostatic hyperplasia (BPH), and prostate adenocarcinoma are major disorders that can be found in all men in different ages.Objectives:The aim of this study was to investigate the association of diet with serum prostate specific antigen (PSA) level as well as prostate volume.Patients and Methods:In this cross-sectional study, 950 men older than 40 years of age who had attended our clinic for a screening program for prostate cancer were enrolled. Data was extracted from the program database. The eligible cases included all noncancerous subjects with available data concerning serum PSA level and prostate volume; the patients had completed a 50-item self-administered food frequency questionnaire about their diet during the preceding two year.Results:No overall association was found between the consumption of foods and prostate volume as well as serum PSA level. There was a significant correlations between age and serum PSA level (r = 0.24) as well as with prostate volume (r = 0.22) (P < 0.001). In addition, there was a significant correlation between serum PSA level and prostate volume (r = 0.41 and P < 0.001).Conclusions:The results of this study confirmed the previous reports regarding the serum PSA level correlation with prostate volume. There was no evidence that dietary patterns might have any important effect on prostate volume and serum PSA in this Iranian population.

Hyoscine N-butyl bromide could reduce the severity of CRBD related to TURP in patients with BPH and their need for analgesic consumption either. It shortened the length of stay in the recovery room. Regarding its availability and low cost, it can be an effective pain relief drug for CRBD discomfort related to TURP in BPH patients.

Objective: To determine the optimal cutoff value for follicle stimulating hormone (FSH) to predict the outcome of microsurgical testicular sperm extraction (micro-TESE) in patients with nonobstructive azoospermia (NOA). Subjects and methods: We included a total number of 180 patients with NOA. The serum level of FSH was determined and all the subjects underwent micro-TESE. We determined the optimal cutoff value for FSH and assessed whether the test could be effectively used as a successful predictor of sperm retrieval by calculating the Receiver Operating Characteristic (ROC) area under the curve. Results: Overall we included a total number of 171 patients with mean age of 34.3 ± 8.6 years. The micro-TESE was considered to be successful in 79 (43.8%) while it failed in 92 (56.2%) patients. We found that the mean level of serum FSH was significantly higher in group those with failed micro-TEST compared to successful group (p < 0.001). The cutoff value for FSH was calculated to be 14.6 mIU/mL to predictive the outcome of micro-TESE with a sensitivity of 83.5% [73.5%-90.9%] and a specificity of 80.3% [69.5%-88.5%]. At this value, the other parameters were calculated to be PPV, 81.5%; NPV, 82.4; LR+, 4.23; and LR-, 0.21. Conclusions: The results of the current study indicate that FSH plasma levels above 14.6 mIU/mL can be considered to be the failure predictor of the micro-TESE in NOA patients.

Background and Objective: Today's, the Gleason grading system is well known as the world's most commonly used histological system for prostate cancer. It provides significant information about the prognosis. This prospective paper assessed the correlation of transrectal ultrasound (TRUS) guided biopsy and radical prostatectomy specimens in terms of Gleason scores. In this matter, the effect of PSA density (PSAD) and prostate size on the Gleason scores were explored.Methods: This paper is conducted as a prospective study in which the medical records, comprised the pathology reports, of 68 patients with prostate cancer who underwent radical retropubic prostatectomy. Then, the preoperative Gleason score was compared to the Gleason score of the prostatectomy specimen.Results: Patients age ranged from 59 to 79 years, in which the median was 64 years. The comparison of the Gleason scores from the biopsy and radical prostatectomy specimens revealed that it was only identical in 24 out of 68 (35.3%) cases. On the other hand, the mean Gleason score obtained from the TURS biopsy was 6.4, compared with a mean score of 7.1 on the radical prostatectomy specimens. Meanwhile, there was a significant difference between Gleason scores (P<0.001). The experimental results confirmed that PSAD in 0.195, 0.22, 0.23, 0.25 cut of points had both high specificity and sensitivity for concordance of TRUS biopsy result using the Radical prostatectomy. Conclusion:This study provides evidence that the Gleason scores of the needle prostate biopsies and those of the radical prostatectomy specimens were concordant in some cut off points of PSAD especially between 0.195 -0.28. Therefore, it has seemed that PSAD can be a proper scale to determine the concordance of TRUS biopsy result using the Radical prostatectomy.