Association of Diet With Prostate Specific Antigen and Prostate Volume

Shirazi, Mehdi; Ariafar, Ali; Zeyghami, Shahryar; Hosseini, M.; Khezri, Abdol Aziz

doi:10.5812/numonthly.19411

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…Previous studies by Shirazi and colleaques also reported a significant correlation between age and serum PSA level as well as with prostate volume [18]. The authors further stated that a significant correlation existed between serum PSA level and prostate volume and therefore acute urinary retention [18,27]. These findings are conflicting considering the reports of Bhagya et al [28].…”

Section: Pearson's Correlation Study For Bph With or Without Renal Imcontrasting

confidence: 56%

“…Serum PSA trends over time (PSA velocity), measurement of free versus complexed PSA, and PSA density may help to improve the specificity of PSA testing in men with BPH. Previous studies by Shirazi and colleaques also reported a significant correlation between age and serum PSA level as well as with prostate volume [18]. The authors further stated that a significant correlation existed between serum PSA level and prostate volume and therefore acute urinary retention [18,27].…”

Section: Pearson's Correlation Study For Bph With or Without Renal Immentioning

confidence: 80%

“…an important male reproductive system gland and its disorders such as benign prostatic hyperplasia (BPH) can affect men's quality of life and health [18]. Prostate specific antigen is a widely used tumor marker in the screening and management of BPH and prostate cancer.…”

Section: Pearson's Correlation Study For Bph With or Without Renal Immentioning

confidence: 99%

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Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Emeje¹,

Ukibe²,

Onyenekwe³

et al. 2017

J Bioanal Biomed

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between signs and symptoms of BPH and RI in their population-based sample of 467 white men [9]: there was a significant association between RI and BPH. Studies in Africa have shown that countries like Ghana, Nigeria, and Cameroon have similar prevalence of 25% of Benign Prostatic Hyperplasia in kidney disease [10]. In the United State of America, 13.6% of men with BPH have been reported to have chronic renal failure [11]. The impact of BPH and renal impairment on health should not be underestimated as it accounts for about 10% of hospital admission in Nigeria [6]. The most successful approach to detect BPH is the use of percent fPSA= fPSA × 100/tPSA, where f=free and t=total AbstractBackground: Prostate disorders (prostatitis, BPH and Pca) can contribute to renal impairment. Benign prostatic hyperplasia (BPH) and renal impairment (RI) such as chronic kidney disease are important public health problems in older men. The present study aimed to assess serum levels of prostate specific antigen, urea, creatinine, protein and uric acids in subjects with BPH at Federal Medical Center, Lokoja, Kogi State, Nigeria. A population-based sample of one hundred and ten (110) men aged (51-70) years were conveniently recruited and divided into three groups designation A= BPH with RI, (n=35) B=BPH without RI, (n=35) and C=Control, (n=40).Methods: Blood samples were collected from all the participants and serum separated and stored at -20˚C until analyzed for prostate specific antigen using Enzyme Linked Immunosorbent Assay (ELISA) and colorimetric assay method for creatinine, urea, protein and uric acid. Data were analyzed using SPSS software application (version 17.0). Pearson correlation and Receiving Operating Characteristics of the groups were done. Results:The result showed that urea and creatinine levels were significantly higher in BPH subjects with or without renal impairment when compared with controls (p<0.05 respectively). Similarly, total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), complex prostate specific antigen (cPSA) and percent free prostate specific antigen (%fPSA) were significantly higher in BPH subjects with or without RI when compared with controls (p<0.05 respectively). Urea, creatinine and uric acid were significantly higher while total protein was significantly lower in BPH with RI when compared with BPH without RI (p<0.05 respectively). Conclusion:The significantly higher urea, creatinine and uric acid levels in BPH subjects showed that BPH subjects with RI may have decrease excretion and accumulation of uric acid by the kidney suggesting possible risk of progression to CKD while BPH subjects without RI tends to be more prone to developing renal dysfunction. The significant correlation between %fPSA, creatinine and urea shows an association between BPH and renal diseases. Using receiving operating characteristic (ROC) curves to assess diagnostic performance of various parameters in various groups for the prediction of BPH with or without renal disease, there was evidence tha...

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Section: Pearson's Correlation Study For Bph With or Without Renal Imcontrasting

confidence: 56%

Section: Pearson's Correlation Study For Bph With or Without Renal Immentioning

confidence: 80%

See 1 more Smart Citation

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Emeje¹,

Ukibe²,

Onyenekwe³

et al. 2017

J Bioanal Biomed

View full text Add to dashboard Cite

show abstract

“… 17 Also, the adverse effects of BPH are relatively apparent in men >50 years of age. 18 19 According to the results of this study, among Chinese adults with LUTS/BPH, PV and LUTS deteriorated as age increased. Indeed, Shi et al 18 and Chokkalingam et al 17 selected age ≥50 years as an inclusion criterion for studying BPH.…”

Section: Discussionmentioning

confidence: 76%

“…According to Zhang et al , 26 the frequency of animal protein intake is positively correlated with PV. However, according to Shirazi et al , 19 no relationship was detected between dietary patterns and PV. Second, the relationship between diet and BPH is mixed.…”

Section: Discussionmentioning

confidence: 95%

Relationship among diet habit and lower urinary tract symptoms and sexual function in outpatient-based males with LUTS/BPH: a multiregional and cross-sectional study in China

Chen

Zhou

et al. 2016

BMJ Open

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ObjectivesThis study assessed the effect of diet habits on lower urinary tract symptoms (LUTS) and sexual function in Chinese men with LUTS/benign prostatic hypertrophy (LUTS/BPH).SettingMulticentre study conducted between July 2013 and December 2013 in 11 hospitals in 3 geographic regions in China.ParticipantsOverall, participants with LUTS/BPH accounted for 61.4% (2584/4208) of the respondents, whose data were processed in the following statistical analysis.Primary and secondary outcome measuresLUTS and sexual function were assessed based on the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function 5 (IIEF-5) score. Prostate volume (PV) was determined by ultrasound.ResultsA total of 4208 participants met the inclusion criteria. The average age of the whole participants was 65.8±7.7 years. Overall, participants with LUTS/BPH accounted for 61.4% (2584/4208) of the respondents, whose data were processed in the following statistical analysis. Generally, prostate enlargement was greatest in south China. LUTS and male sexual dysfunction (MSD) were most severe in northwest China. Based on multivariable analysis, PV enlarged as the age (p<0.001), body mass index (BMI; p<0.001) and vegetable intake (p<0.001) increased. Age (p<0.001) and BMI (p<0.05) independently increased the IPSS. A higher level of education (p<0.001) and more frequent meat, fish and egg intake (p<0.05) decreased the IPSS. Age (p<0.001), BMI (p<0.001), low education level (p<0.05), vegetable intake (p=0.001), and milk and dairy product intake (p=0.001) decreased the IIEF-5 score.ConclusionsIn addition to factors including age, obesity and level of education, dietary habits and geographic difference might also play an important role in the variation of PV, LUTS and MSD for Chinese men with LUTS/BPH.

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Diet as a risk factor and intervention for lower urinary tract symptoms secondary to benign prostatic hyperplasia

Wegrzyn

Kirshenbaum

McVary

2021

Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prostatic

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Association of Diet With Prostate Specific Antigen and Prostate Volume

Cited by 7 publications

References 30 publications

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Relationship among diet habit and lower urinary tract symptoms and sexual function in outpatient-based males with LUTS/BPH: a multiregional and cross-sectional study in China

Diet as a risk factor and intervention for lower urinary tract symptoms secondary to benign prostatic hyperplasia

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