Background: The insatiable need for low-power and high-performance integrated circuit (IC) results in the development of alternative options for metal oxide semiconductor field effect transistor (MOSFET) in the ultra-nanoscale regime. The practical challenge of the device scaling limits the use of MOSFET for future technology nodes. ICs are equipped with billions of transistors whose size must be scaled while increasing performance. As the size of the transistor shrinks for the new technology node, the control of the gate over the channel also reduces, leading to sub-threshold leakage. The non-planar technology is the potential methodology to design the ICs for the future technology nodes. The fin-shaped field effect transistor (FinFET) is the most valuable non-planar technology. High sub-threshold slope, better short channel effect (SCE) control, high current drive strength, low dopant-prompted variations, and decreased power dissipation are the prominent features of FinFET technology. Objective: FinFET is an advanced version of MOSFET in terms of geometrical structure. Therefore, in this review paper, the different geometrical structures, working operations, design challenges, future aspects, and the different configurations of FinFETs are presented. The performance of the different configurations of a 1-bit full adder is evaluated and compared. Methods: An overview of FinFET evolution from the planar MOSFET, along with its architecture supported by the requisite equations, is presented in the paper. Besides this, it also gives an insight into the circuit simulation using the FinFETs for the process voltage temperature (PVT) variations, width quantization, design challenges, and the future of FinFETs. A comparative study of FinFET-based 1-bit full adder using various techniques is done to compute and compare the leakage power, delay, and power delay product (PDP). Results: The full adders using FinFETs show less leakage power and PDP. The AND-OR logic-based hybrid full adder using FinFETs shows the least energy consumption per switching. FinFET-based gate diffusion input adder shows a 74 % reduction in dynamic power compared to the full adder using MOSFET technology. The low power FinFET-based full adder shows a 54.16 % reduction in leakage power compared to the MOSFET-based full adder. The results signify the effect of multi-gates in curbing the leakage power dissipation. Conclusion: MOSFET faces the practical challenge of device scaling and SCEs at lower technology nodes. It initiates the multi-gate technology for future system generation. FinFET has the capability to design low-power and high-performance circuits in an ultra-nanoscale regime. The geometrical structure of FinFET plays a key role to improve the performance metrics in an ultra-nanoscale regime.

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Objective: To assess the effectiveness of topical tacrolimus (TCL) 0.03% dermatological ointment in the treatment of patients with Thygeson superficial punctate keratitis. Study Design: Retrospective Review. Setting: Eye OPD of Qazi Hussain Ahmad Medical Complex, Nowshera. Period: Jan 2019 to Jan 2021. Material & Methods: Twelve patients with Thygeson superficial punctate keratitis (TSPK) were included retrospectively by reviewing their medical records. Eight patients were unresponsive to topical steroids and/or lubricants. Diagnosis was made based on the history and clinical findings. All patients were treated with topical tacrolimus 0.03% dermatological ointment twice a day. We took the following subjective features for assessment i.e. watering of eyes and light sensitivity, while for objective features reduction in the no. of epithelial keratitis, healing of keratitis, surface leveling of the lesion and reduced corneal staining with fluorescein. Results: Out of total 12 patients, 4 were male and 8 females with a mean age of 21 ± 9.42 years. All were having bilateral involvement. Duration of therapy ranged from 02 to 40 weeks (mean 08 weeks). All patients improved symptomatically with resolution of watering of eyes and light sensitivity, while in ocular signs we noted improvement in corneal lesions. The efficacy of therapy was observed 3 days, post application among all patients. No, side effects reported in any of our patients treated with topical TCL dermatological ointment. Conclusion: The safety and efficacy of topical tacrolimus 0.03% dermatological ointment has been observed in patients with Thygeson superficial punctate keratitis who were refractory to conventional therapy.

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