This study aimed to investigate the therapeutic effect of Medical Ozone(MO) in combination with insulin on reproductive hormones and histopathological changes in ovaries of rats with diabetes mellitus (DM). forty eight adult female rats were randomly divided into the following six groups (n = 8): control (A), MO (B), diabetic (C), MOtreated diabetic (E), Insulin-treated diabetic ) E), and MO, Insulin-treated diabetic (F). DM was induced by a single intraperitoneal (ip) Alloxan injection (150 mg/kg ( .after six weeks of treatment Blood sample were collected to estimate biochemical parameters glucose, serum hormones. Also, ovary samples were obtained for histological examination in diabetic untreated rats the results showed hyperglycaemia, and significant decrease in hormones profiles. While ,MO and Insulin treated rats reported an amelioration of the most toxic effect of alloxan and returned most of these parameters nearly normal. Microscopically ovaries showed definite, degeneration in the diabetic group while when use of MO and Insulin treatment in this study showed significant improves of such histological changes when compared to diabetic untreated rats. Conclusion: it was recommended that the use of the Medical Ozone with Insulin as a supplementary agent to reduce oxidative stress damage of hyperglycaemia and recommended to use variable doses and different periods of treatment to evaluate the best dose and period

The purpose of this study is to determine the association between fasting sugar level, urea, creatinine, uric acid, blood pressure, and glomerular filtration rate (GFR) in renal disease patients.The current study found that men patients had lower blood sugar, fasting blood glucose, and serum creatinine levels than women patients. however, there was no significant difference between groups of blood urea, uric acid, Glumoular filter, and blood pressure. Also, there is no significant difference in patients based on age in the current study, and there is a very strong positive link between random glucose level and fasting glucose level.

Miscarriage in the early and late stages of pregnancy is a common problem in women with the anti-phospholipids syndrome. The current study aimed to determine the relationship between the syndrome of antibodies to phospholipid and thyroid hormones among pregnant women in the city of Nasiriyah. Blood samples were collected from (100) pregnant women with recurrent miscarriages due to phospholipid syndrome, the average aged (20-30) and (30-40) years. The results showed a significant increase in T3 and TSH hormones between ages (20-30), (30-40) years compared to the control group, as well as a significant increase in T4 hormone in pregnant women aged (20-30) while the ages group of (30-40) did not notice a significant change in the level of hormone T4 compared with the control group. We conclude that there is a relationship between thyroid hormones and autoimmune diseases.

Rheumatoid arthritis (AR) is one of the chronic diseases resulting in many complications such as cardiovascular disease (CVD). Any change in the lipid profiles and myocardial markers indicates cardiovascular disease risk, so this study is designed to monitor the pattern of lipid profiles and myocardial markers in newly diagnosed RA patients. Blood samples were collected from 70 Iraqi patients newly diagnosed with rheumatoid arthritis (male and female) and 30 healthy served as control. These individuals were aged 35-65 years. The serum samples were obtained to determine myocardial markers; included troponin, creatinine kinase (CK), lactate dehydrogenase (LDH), and glutamic oxaloacetic transaminase GOT; and lipid profiles; such as cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL); using a kit from Roch (Germany), measured automatically with Minividas, Biomerieux (France). No differences between levels of all lipid profiles and myocardial markers in newly diagnosed RA patients compared with the healthy group were found as well as they were within the normal values, but interestingly, the cholesterol/HDL ratio increased significantly in RA patients comparing with healthy, so it could conclude that the risk of CVD could be increase also among the newly diagnosed of RA patients. Moreover, the cholesterol/HDL ratio should be probably included in a model to predict the risk of cardiovascular disease for RA in addition to the gender, age at the disease onset, and severity markers of disease.

The current study was carried in physiology and pharmacology department at college of veterinary medicine, Al-Qadiysia University. The aim of this study was clarified the effect of Coenzyme Q10 in improvement of reproductive efficiency in male Wister rats after exposed to oxidative stress by lead acetate.40 male rats at 60 days old with 135±11gm in weight were divided into four equal groups, The first group was given distilled water with orally gavage for 60 days as control group (C).The second group (T1)wasgiven CoQ10 (200mg/kg/b.w)for 60 days , while the third group (T2) given lead acetate (10mg/kg/b.w) for 60 days. The forth(T4) group was gives lead acetate (10mg/kg/b.w) for 30 days then given CoQ10 for 30 days. At 60 days of experiment all animals were sacrified, sample of testis taken for measure the gene expression of(CYP17 and CPY11), gene expression results were revealed that there is up regulation (p≤0.05) in T1 compared with T2.