Skin aging is a complex biological process influenced by a combination of endogenous (intrinsic) and exogenous (extrinsic) factors. Because of the fact that skin health and beauty is considered one of the principal factors representing overall "well-being" and the perception of "health" in humans, several antiaging strategies have been developed during the last years. It is the intention of this article to review the most important anti-aging strategies that dermatologists have nowadays in hand, including preventive measurements, cosmetological strategies, topical and systemic therapeutic agents and invasive procedures.

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Vildagliptin, an antihyperglycemic drug, is having high water solubility and shorter elimination half-life. This leads to administer vildagliptin frequently to maintain its therapeutic efficacy. So the Formulation of vildagliptin microspheres might be beneficial in overcoming the side effects of the conventional drug delivery systems during the prolonged treatment. The aim of the work was to evaluate and fabricate the microspheres, which improved the absorption of drug and increase the release kinetics and also to study the effect of formulation variables. The microspheres of vildagliptin were formulated by solvent evaporation technique. The formulation variables were the concentration of Ethyl cellulose (EC), Polyvinyl alcohol (PVA), and stirring speed. The resulting microspheres were evaluated for percentage yield, percentage entrapment efficiency, particle size, surface morphology, drug release rates. The morphological structure of the microspheres revealed spherical shaped structures. Good entrapment were observed. The in vitro drug release was found to be controlled. Results indicated that physicochemical properties of microspheres strongly affected by the presence of drug/polymer ratios, changing the concentrations of them and effect of variables.

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A simple, accurate, precise, cost effective, rapid and sensitive UV/visible spectrophotometric method was developed for the determination of Vildagliptin in active pharmaceutical dosage form. The developed method was validated as per ICH guidelines.The purity of Vildagliptin was characterized by melting point, Fourier Transform Infra-Red and DSC. The drug was analyzed using UV/visible spectrophotometric method was validated in terms of linearity and range. The solvents used was water, 0.1 N HCl and phosphate buffer pH 7.4 and the wavelength corresponding to maximum absorbance of the drug were found at 210 nm.Melting point of drug was found 151.67°C nearly corresponds to its actual melting range. The linear response for concentration range of 2-12 µg/ml of vildagliptin for water, 0.1 N HCl and phosphate buffer pH 7.4 was recorded each with regression coefficient R = 0.9998, 0.9994 and 0.9991 respectively.The drug was confirmed by interpretation of UV spectra. Hence, proposed method stands out validated and shows a linear relationship and thus may be used for routine analysis of Vildagliptin in pharmaceutical dosage forms.