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A investigação fitoquímica da resina de Amburana cearensis A. C. Smith permitiu o isolamento de um novo composto: 3',4'-dimetóxi-1'-(7-metóxi-4-oxo-4H-cromen-3-il) benzo-2',5'-quinona (1), juntamente com seis compostos conhecidos e identificados como: 4,2',4'-triidroxichalcona (2), 7,8,3',4'-tetrametoxiisoflavona (3), 4,2',4'-triidroxi-3metoxichalcona (4), 3,4,5-trimetoxicinamaldeido (5), 3',4'-dimetoxi-7-hidroxiisoflavona (6) e 6,7,4'-trimetoxi-3'-hidroxiisoflavona (7). As estruturas foram estabelecidas com base na análise dos dados espectrométricos de: IV, EI-EM, HR-ESI-EM e RMN incluindo experimentos 2D. Phytochemical investigation of the resin of Amburana cearensis A. C. Smith allowed the isolation of a new compound: 3',4'-dimethoxy-1'-(7-methoxy-4-oxo-4Hcromen-3-yl)benzo-2',5'-quinone (1), together with six known compounds identified as: 4,2',4'-trihydroxychalcone (2), 7,8,3',4'-tetramethoxyisoflavone (3), 4,2',4'-trihydroxy-3methoxychalcone (4), 3,4,5-trimethoxycinnamaldehyde (5), 3',4'-dimethoxy-7-hydroxyisoflavone (6) and 6,7,4'-trimethoxy-3'-hydroxyisoflavone (7). The structures were established from the IR, HR-ESI-MS and NMR spectral data, including 2D-NMR experiments.

Dengue is a worldwide public health problem; studies show a correlation between dengue and climatic variables. Thus, this research aimed to investigate the correlation of the number of cases of patients with primary dengue symptoms (NCPPDS) with the compensated average temperature (TCA), average precipitation (PA) and compensated average relative humidity (RHCA) for the state of Ceará (2013-2018), in addition to identifying the municipalities most affected by the disease. For this analysis, institutional databases were collected and the data were compiled and processed through Statistical Package for the Social Science software. The association between climatic variables and NCPPDS was made using Pearson's correlation. It was noted that the city of Fortaleza was the municipality most affected by the disease, followed by its metropolitan region. Pearson's correlation was significant and inversely proportional between the NCPPDS and TCA in the years studied. In the NCPPDS analysis and PA, a directly proportional significant correlation was observed in the years 2013, 2017 and 2018. Regarding RHCA during the years 2013, 2015, 2017 and 2018, a directly proportional significant correlation to dengue cases was also observed. These results showed that precipitation and humidity directly influenced the number of dengue cases in the state of Ceará, and in accordance with studies in other Brazilian regions, these findings represent a general picture for dengue spreading.

Os óleos essenciais (OES) de Ocimum gratissimum e Cymbopogon citratus apresentam diversas ações fitoterápicas. Nesse trabalho o objetivo foi microencapsular os OES destas plantas, para avaliar as características química-biológicas das micropartículas através da análise por infravermelho e pelo ensaio citotóxico. A extração dos óleos se deu por hidrodestilação e a microencapsulação foi realizada em Spray Drier. Na análise de infravermelho notou-se que não há aparecimento de novas bandas de absorção, o que é útil nos processos de microencapsulação. O ensaio citotóxico mostrou que não há citotoxicidade das micropartículas nas concentrações testadas. Portanto, as micropartículas estão protegidas e não são tóxicas, características importantes para um produto para ensaios biológicos in vitro e in vivo.Palavras-chave: Encapsulação. Infravermelho. Citotoxicidade.