We use Brownian dynamics (BD) simulations to probe the physics of nonequilibrium polymer compression in extreme nanoconfinement. In our system, modeled on the “nanodozer assay”, a gasket translating at a fixed sliding speed impinges on a nanochannel extended chain. In square channels with diameter much smaller than the chain persistence length, we find that chain compression proceeds through a unique folding kinetics driven by repeated double-fold nucleation events and growth of nested folds. We show that the folding kinetics can be understood by coupling a theory for deterministic contour spooling across the folds with a dynamically varying energy landscape for fold nucleation. These findings are critical for understanding compression of nanochannel confined DNA in the sub-persistence length (Odijk) regime.

Background. The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppression and reduce the risk of COVID-19 and manage infection in solid organ transplant recipients (SOTr) is needed. Methods. Iterative literature searches were conducted, the last being January 2021, by a team of 3 information specialists. Stakeholders representing key groups undertook the systematic reviews and generation of recommendations using a rapid response approach that respected the Appraisal of Guidelines for Research and Evaluation II and Grading of Recommendations, Assessment, Development and Evaluations frameworks. Results. The systematic reviews addressed multiple questions of interest. In this guidance document, we make 4 strong recommendations, 7 weak recommendations, 3 good practice statements, and 3 statements of "no recommendation." Conclusions. SOTr and patients on the waitlist are populations of interest in the COVID-19 pandemic. Currently, there is a paucity of high-quality evidence to guide decisions around deceased donation assessments and the management of SOTr and waitlist patients. Inclusion of these populations in clinical trials of therapeutic interventions, including vaccine candidates, is essential to guide best practices.

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This paper presents results based on direct experimental measurements of tangential (Et) and normal (En) E-field components along the stress grading system (SGS) of a real stator bar (Roebel type) for different AC 60 Hz applied voltages. These measurements were made with a new electro-optic system allowing for the study of both spatial distributions of two E-field components along the bar and their temporal evolution at critical points. The results obtained allowed us to calculate the correlation between the distribution of En and Et along the SGS. In particular, it was demonstrated that the En distribution presents a characteristic minimum, which can be used to identify the zone of partial discharge inception. Moreover, it was possible to observe an enlargement of the Et component distribution followed by a saturation in magnitude with the applied voltage increase. Moreover, the results have demonstrated that the waveform of the En component is mostly affected by the SG material used, producing a greater distortion in its waveform than those obtained for the Et component. The more significant distortion was obtained at the end of the outer corona protection (OCP) material, corresponding to the first maximum of the En component and characterized by the appearance of a third harmonic of large amplitude.

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