Objectives: The genetic basis of periodontitis was demonstrated by formal genetic studies which were focused on a range of various candidate genes selected for their roles in the immune system like genes of the interleukins (IL). Bone proresorptive cytokines such as IL-1 and tumor necrosis factor-α are primarily regulated by a network of other T-cell derived cytokines, including IL-12 family. Specific objective of this study was to find out any association between IL-12β 3΄ untranslated region (UTR) (rs7709212) gene polymorphism and chronic as well as aggressive periodontitis (AgP) in Bengali population of West Bengal, India. Materials and Methods: A total of 88 Bengali participants of both sexes were recruited and were divided into three groups: Group A (chronic periodontitis [CP] group), Group B (AgP group), and Group C (healthy control). DNA extraction from collected peripheral venous blood was performed by phenol chloroform method and ethanol precipitation. Genotyping of extracted DNA samples was carried out for locus IL-12β 3΄UTR (rs7709212) by real time-polymerase chain reaction. Association between genotypes and cases was examined by the odds ratio with 95% confidence interval and chi-square analysis using R statistical software. Statistical significance was defined as P < 0.05. Results: On analysis of the minor allele frequencies of total periodontitis cases and control, the results were found to be statistically significant with the P = 0.03045. Conclusion: The present study suggested a strong association of single nucleotide polymorphism of IL-12β (rs7709212) with total periodontitis cases (both CP and AgP) in the present study cohort.

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The aim of periodontal regenerative therapy is to restore original architecture and function of lost periodontal tissues, as a result of trauma or following destructive periodontal diseases. This review includes the biological principles and efficacy and effectiveness of different biomaterials and factors affecting periodontal regeneration. Various human clinical trials showed a successful periodontal regeneration with different biomaterials. However, postoperative plaque control is one of the key factors influencing periodontal healing following regenerative periodontal therapy. A strong native regenerative potential of the periodontium can be conciliated by local and systemic factors.

Pyogenic granuloma (PG) is hyperplastic inflammatory lesion or growth occurring due to constant irritation, traumatic injury, or hormonal factors. PG can occur on the skin and oral cavity. In the oral cavity, it most often occurs in the gingiva. Other oral sites involved are buccal mucosa, lip, tongue, and palate. Histopathological examination is crucial for its accurate diagnosis as it can be misdiagnosed due to its clinical resemblance with peripheral ossifying fibroma, peripheral giant cell granuloma, hemangioma, and fibroma. Here, we present a case of an 18-year-old male having a lesion in the mandible anterior region in the lingual aspect of the gingiva.