Objective: Aim of the study is to find out the microbiological profile and their antibiotic sensitivity patterns in patients with chronic suppurative otitis media in a tertiary care hospital. Materials and methods:A total number of 100 ear swabs were investigated for the present study. Their gram staining, direct microscopy with KOH, culture sensitivity, and biochemical tests were carried out to identify the organisms and to know their sensitivity pattern. All the swabs were collected from patients with clinical diagnosis of chronic suppurative otitis media visiting otolaryngology outpatient department of tertiary care hospital. The study period was one year, from July 2016 to June 2017. Results:Out of 100 swabs ,fungal culture was positive for 28 (28% ) swabs , while combined growth of fungi and bacteria obtained from 24 (24%) swabs, only bacteria from 62 (62%) and culture was negative from 10 swabs. Pseudomonas aeruginosa (37.21%) was commonly isolated organism followed by Staphylococcus aureus (27.91%). Fungal was isolated in 28 cases, out of which 57.14% were Aspergillus species, followed by Candida (42.86%). Amikacin was found to be the most effective antibiotic with low resistance rate. Conclusion:The study of microbial pattern and their antibiotic sensitivity determines the prevalent organisms causing chronic suppurative otitis media in local area and helps to start appropriate treatment of otitis media and its complications for successful outcome.

<p class="abstract"><strong>Background:</strong> Chronic otitis media (COM) is an inflammatory process in the middle ear space that results in long-term changes in the tympanic membrane including atelectasis, dimeric-membrane formation, perforation, tympanosclerosis, retraction pocket or cholesteatoma. COM can be classified into healed, inactive (mucosal or squamosal), active (mucosal or squamosal). Myringoplasty is tympanoplasty without ossicular reconstruction. Cortical mastoidectomy is usually accompanied by tympanoplasty. Aim was to assess and compare the efficacy of myringoplasty with cortical mastoidectomy in dry and wet mucosal type of COM, in terms of graft uptake and hearing improvement.</p><p class="abstract"><strong>Methods:</strong> A prospective study, where 30 patients each of wet and dry mucosal-type COM were included. Patients underwent myringoplasty with cortical mastoidectomy. All were followed up for 6 months, both the groups were statistically compared.  </p><p class="abstract"><strong>Results:</strong> In our study, mean age of patients in group A (wet COM) was 34.13 years and group B (dry COM) was 33.36 years. Group A had success rate of 90% and group B had success rate of 86.6%. There was no statistical significance (p value- 0.53) on comparing both groups with respect to graft uptake. There was significant hearing improvement post-operatively in both the groups (p&lt;0.05). However, there was no significant difference between the groups (p value- 0.66). This shows that presence of discharge at the time of surgery does not interfere with the results of cortical mastoidectomy with myringoplasty.</p><p class="abstract"><strong>Conclusions:</strong> We conclude that, there is good outcome in both wet and dry COM following myringoplasty with cortical mastoidectomy with respect to graft uptake and hearing improvement.</p>