Background and Objective — Tempe (fermented soybean) has the potential as an affordable nutritional support alternative during tuberculosis (TB) infection. The purpose of the study was to assess the efficacy of supplementation with the ethanolic extract of Tempe on the oxidative stress markers alleviation and histological changes in male Wistar rats infected with Mycobacterium tuberculosis. Material and Methods — Thirty-five male Wistar rats were divided randomly into five groups and infected by Mycobacterium tuberculosis strain H37RV intratracheally. Total antioxidant capacity (TAC) and Thiobarbituric Acid Reaction (TBARS) levels were assessed using a colorimetric method while C-reactive protein (CRP) was measured by Elisa method. The lung damage was scored using histopathological parameters. Results — There were no significant differences in the TBARS levels and CRP concentrations compared to control. Tempe extract increased the TAC level at 200 (p=0.011), 400 (p=0.027), and 800 (p=0.029) kg/body weight concentrations compared to control. Perivasculitis and alveolitis mean scores were lower (p<0.05) than control in all supplement groups. Additionally, the mean scores of peribronchiolitis among supplementation groups were decreased (p<0.05) in the 200 and 800 mg/kg body weight, while the granuloma mean score was lower in the 800 mg/kg body weight compared to control. Conclusions — Tempe extract may have a weak efficacy in improving the antioxidant capacity and lung histological condition in TB rat models.

Gandarusa (J. gendarussa Burm. f.) is an etnomedicine which is used as a male contraceptive alternative, known to inhibit the enzymefunction of spermatozoa hyaluronidase during fertilization. One of the ideal contraceptive conditions is the safetyness (among others nonmutagenic), requiring a long research during the verification process. The early research is the gene expression of hyaluronidase mice(M.musculus L.) testis given water fraction of the gandarusa with PCR analysis. The total RNA was isolated from the normal mice testis(as the negative control or no treatment group) and the mice testis from the treatment groups. The treatment groups consisted of group Iand II treated with water fraction of the gandarusa 15 mg/20 gr BW and 7.5 mg/20 gr BW, subsequently, the positive control group wasalso given hesperidins 1 mg/20 gr BW once a day per oral during the 1.5 times of spermatogenesis cycle (for 55 days). The results of thestudy showed that (1) the cDNA fragment confirmed as the gene of hyaluronidase mice testis (with 710 bp length of nucleotide) passedthrough RT-PCR at the total RNA negative control group, sequenced, isolated and alignment in the NCBI gene bank. (2) the same cDNAfragment gene of hyaluronidase mice testis (from the negative control group) did not transcript in the treatment I and positive controlgroups (where there is no band), but this gene will be transcripted in the treatment II group (where the band is emerged).

No abstract

Various universities founded as research universities in the 19th century conducted research that assisted the progress of various fields in European and American countries. Research universities/research-based universities are characterized by the presence of research activities in the Tri Dharma of Higher Education. Several universities in Indonesia have declared themselves to be research universities, and others are in the process of doing so. Research universities must meet various indicators, all of which stem from research activities. The purpose of this paper is to investigate and compare the readiness of Universitas Wijaya Kusuma Surabaya (UWKS) to become a research university. One method for achieving these goals is the formation of research groups. This essay uses a narrative review design. A UWKS is a private university founded in 1981 in Surabaya, East Java. A long track record of research since its establishment is sufficient provision to prepare it to become a research university. This is also supported by the university's academic community and the foundation that manages it, when viewed from the vision, mission, and objectives. The formation of various research groups could be the start of the development of research universities. They will enable lecturers to produce targeted outputs as indicators of research performance, such as research groups for early detection of chronic degenerative diseases based on specific Indonesian polymorphisms. The paper's conclusion was that UWKS has the potential to become a research university based on its track record. The formation of many research groups is one way to accomplish this.

No abstract