A research on red fruit (Pandanus conoideus Lam.) has been conducted to determine its hepatoprotective effect. This research was concern on three group of treatments, a blank treatment (water), a standard drug (curcumine containing) and red fruit extract treatment group. The liver destruction was induced by CCl 4 . The hepatoprotective effect was illustrated by SGOT -SGPT level of activity and percentage of cell destruction obtained from histopatogolic analysis. Compared to the blank group, which had level of SGOT-SGPT activity as 38224,40  2,92 U/L and SGPT of 24128,00  5,22 U/L, the red fruit treatment group showed a lower SGOT -SGPT activity (20112,4  2,68 U/L and 18923,0  2,77 U/L, respectively); while the standard drug treatment group showed level of SGOT and SGPT activity as 29732,4  1,85 U/L and 20640,8  3,78 U/L, respectively. The histopatologic evaluation also illustrated similarity that the red fruit treatment group occupied the lowest percentage of hepatocyte destruction shown as percentage of cell degeneration and cell necrosis of 28,3% and 31,7%, respectively. The standard drug treatment showed 78,3% of destruction based on degenerative cell destruction and 88,3% based on cell necrosis. Almost 100% of cell destruction was shown in the blank group. Based on these result, the red fruit extract possessed a liver cell protection activity against cell destruction caused by CCl4 exposure and even more active than a standard drug.