Neoplasm; Endodermal Sinus Tumour;Female; Ovary Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify the site of origin to administer appropriate treatment.The current study reported the case of a 30-year-old married parous female presenting with abdominal distention and pain of two months duration. She had regular menstrual cycles. Based on lab investigations her serum AFP level was markedly raised to 34,244 ng/mL (normal range: 0-9 ng/mL). Computerized tomography (CT) scan showed large lobulated heterogeneous mass in both ovaries and omental, gall bladder, and lung metastasis. A CT guided biopsy of the ovarian mass was done. On histopathology, a differential diagnosis of hepatoid variant of yolk sac tumor, hepatoid carcinoma of ovary and hepatoid tumor arising from gall bladder metastasizing to the ovary were observed. Patient underwent surgery. Per operatively gross ascites with bilateral ovarian mass, extensive omental, pelvic, and gall bladder deposits were observed. Bilateral salpingo-oophorectomy with omental deposit biopsy was conducted. Histopathology along with immunohistochemistry confirmed a diagnosis of hepatoid variant of yolk sac tumor in both ovaries with widespread intra-abdominal metastasis.

typically affecting the back. 3 Scleredema can also follow infectionusually streptococcal and frequently affects women and children. It has an acute onset, and resolution can take 2 years. Scleredema associated with hypergammaglobulinemia typically develops insidiously and persists. It can also be associated with autoimmune disorders. 4 A review of 33 patients with scleredema documented four cases involving the lower limbs; however, this was in addition to the typical distribution. 1 Rongioletti and colleagues 3 documented 44 cases of scleredema; five of these had thigh involvement. Farrell and colleagues 5 reported a patient with diabetes where scleredema affected the thighs. Miyagawa and colleagues 4 published a case of widespread scleredema in association with rheumatoid arthritis and Sjogren syndrome.Our case reminds physicians of this rare condition associated with rheumatoid arthritis.

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