Acute heart failure itself is a life-threatening medical condition that needs urgent medical attention. The cases of acute heart failure are expected to rise in the future due to the increase in life expectancy and advancement of therapy of myocardial infarct that causes the improvement of life expectancy among patients with decreased cardiac function. This study was aimed to obtain the characteristics of acute heart failure patients at Prof. Dr. R. D. Kandou from January to December 2018. The results showed a total of 130 patients that had acute heart failure in 2018, however, only 89 patients fulfilled the inclusion criteria consisting of 52 males (58%) and 37 females (42%). The highest percentages among the patients’ character-istics were, as follows: age >60 years (55%), hypertension as the etiology (37%), hemodynamic profile was wet-warm (56.2%), ejection fraction <40% on echocardiography (41.6%), atrial tachycardia/flutter/fibrillation on ECG (39.1%), CTR >50% on X-ray images (98%), and diuretics usage inpatients and outpatients (89% and 82%). In conclusion, the majority of patients with acute heart failure in 2018 were male, age >60 years, had hypertension as the etiology, wet-warm hemodynamic profile, ejection fraction on echocardiogram <40%, atrial tachycardia/flutter/fibrillation on ECG, CTR >50% on X-ray images, and diuretics usage.Keywords: acute heart failure, characteristics of patients Abstrak: Gagal jantung akut merupakan suatu kondisi medis yang mengancam jiwa dan membutuhkan penanganan yang cepat dan tepat. Kejadian gagal jantung diperkirakan akan semakin meningkat di masa depan, karena semakin bertambahnya usia harapan hidup dan berkembangnya terapi penanganan infark miokard yang mengakibatkan perbaikan harapan hidup penderita dengan penurunan fungsi jantung. Penelitian ini bertujuan untuk mendapatkan karakteristik pasien gagal jantung akut di RSUP Prof. Dr. R. D. Kandou periode Januari-Desember 2018. Hasil penelitian mendapatkan total pasien gagal jantung akut sebanyak 130 orang dan yang memenuhi kriteria inklusi sebanyak 89 orang, terdiri dari 52 orang (58%) laki-laki dan 37 orang (42%) perempuan. Persentase tertinggi pada karakteristik pasien ialah usia >60 tahun (55%), etiologi hipertensi (37%), profil hemodinamik wet-warm (56,2%), fraksi ejeksi pada ekokardiogram <40% (41,6%), gambaran EKG atrial takikardia/flutter/fibrilasi (39,1%), CTR >50% pada foto polos dada (98%), dan penggunaan obat diuretik baik selama perawatan dan saat keluar rumah sakit (89% dan 82%). Simpulan penelitian ini ialah mayoritas pasien gagal jantung akut pada tahun 2018 berjenis kelamin laki-laki, usia >60 tahun, etiologi hipertensi, profil hemodinamik wet-warm, fraksi ejeksi pada ekokardiogram <40%, gambaran EKG atrial takikardia/ flutter/fibrilasi, CTR >50% pada foto polos dada, dan penggunaan obat diuretik.Kata kunci: gagal jantung akut, karakteristik pasien

Erectile dysfunction (ED) is common among cardiovascular disease (CVD) patients. It is an important component of the quality of life. Moreover, it also confers an independent risk for future CV events. There is usual a 3-year time frame between the onset of ED symptoms and a CV event which offers an opportunity for risk mitigation. Thus, sexual function should be incorporated into CVD risk assessment for all males. Algorithms for the management of patient with ED have been proposed according to the risk for sexual activity and future (comprising of both lifestyle changes and pharmacological treatment) improve overall vascular health, including sexual function. Proper sexual counselling improves the quality of life and increase adherence to medication. Testosterone assessment may be useful for both diagnosis of ED, risk stratification, and further management. There are issues to be addressed, such as whether PDE5 inhibitors reduce CV risk. Management of ED requires a collaborative approach and the role of the cardiologist is pivotal.Keywords: cardiovascular disease, erectile dysfunction, sexual functionAbstrak: Disfungsi ereksi (DE) umumnya ditemukan pada pasien dengan penyakit kardiovaskular. DE merupakan komponen penting terhadap penurunan kualitas hidup pada laki-laki dan merupakan indikator terhadap risiko kejadian penyakit kardiovaskular di masa depan. Terdapat jangka waktu sekitar 3 tahun antara munculnya DE dan kejadian penyakit kardiovaskular, sehingga masih ada kesempatan untuk mencegah risiko yang akan terjadi. Dengan demikian fungsi seksual harus dimasukkan dalam penilaian risiko penyakit kardiovaskular pada semua laki-laki. Algoritma untuk penanganan pasien DE telah dirumuskan sesuai dengan risiko aktivitas seksual dan kejadian penyakit kardiovaskular di masa depan. Beberapa pendekatan untuk mengurangi resiko penyakit kardiovaskular terdiri dari perubahan gaya hidup dan pengobatan farmakologi dapat meningkatkan kesehatan termasuk fungsi seksual. Konseling seksual yang tepat dapat meningkatkan kualitas hidup dan meningkatkan kepatuhan terhadap pengobatan. Penggunaan testosteron dan inhibitor PDE5 dapat bermanfaat dalam pengobatan DE. Penanganan DE memerlukan kerjasama dari berbagai bidang spesialistik termasuk peran dari kardiologis.Kata kunci: disfungsi ereksi, fungsi seksual, penyakit kardiovaskular

BACKGROUND: Single-nucleotide polymorphism in the stromal cell-derived factor-1 (SDF-1)/CXCL12 gene had been associated with an increased risk of coronary artery disease (CAD). However, several published studies have shown inconsistent results. AIM: A meta-analysis was assessed to evaluate the association between SDF-1 3’A-gene polymorphism and CAD in the literature. METHODS: A systematic review was conducted in accordance with PRISMA guidelines and adhering to the Cochrane Handbook for Systematic Reviews. The literature search strategy was carried out on April 3, 2019, from PubMed, EBSCO, Google Scholar, and DOAJ during 2013–2018 period using various keywords related to SDF-1, CXCL12, polymorphism, and CAD. Original data from the group, case-control study, English full-text, and DNA polymorphism assessment using polymerase chain reaction were enrolled. Gene polymorphism in A-base nucleotide among patients with CAD and healthy subjects were evaluated. All data were analyzed using Review Manager 5.3 (Cochrane, Denmark) for meta-analysis. RESULTS: Five eligible studies extracted for data analysis (2013–2018) based on the assessment of 2-independent reviewers. Several studies have been excluded due to irrelevant criteria evaluated. A significant result was found between SDF-1 3’A gene polymorphism with the increased risk of CAD in the overall effect evaluation using a fixed-effects model (odds ratio [OR]: 2.02; 95% confidence interval 1.54-2.65; I2: 34%; p<0.001) on the forest plot. CONCLUSION: Our meta-analysis suggests that gene polymorphism in A-base nucleotide of SDF-1/CXCL-12 was associated with the susceptibility of CAD. However, a bigger-scale and well-design of case-control study should be conducted to clarify these conclusions.

Acute cardiogenic pulmonary edema is a common disease, harmful and lethal with a mortality rate 10-20%. Cardiogenic pulmonary edema or edema volume overload due to an increase of pulmonary capillary hydrostatic pressure that causes the increase of transvascular fluid filtration. The increase of pulmonary capillary hydrostatic pressure is usually caused by the increase of pressure in the pulmonary veins that occur due to the increase of left ventricular end-diastolic pressure and left atrial pressure. Clinical features of cardiogenic pulmonary edema are inter alia shortness of breath that is associated with a history of chest pain and heart disease. Cardiogenic pulmonary edema is one of medical emergencies that need early medical treatment after the diagnosis is established. The management includes supportive treatment to maintain lung function (such as gas exchange, organ perfusion), where as the main cause should be investigated and treated as soon as possible whenever possible. The principle of management are adequate oxygen distribution, fluid restriction, and maintain cardiovascular function. The initial consideration are clinical evaluation, ECG, chest x-ray and blood gas analysis.Keywords: acute cardiogenic pulmonary edema, managementAbstrak: Edema paru kardiogenik akut merupakan penyakit yang sering terjadi, merugikan dan mematikan dengan tingkat kematian 10-20 %. Edema paru kardiogenik atau edema volume overload terjadi karena peningkatan tekanan hidrostatik dalam kapiler paru yang menyebabkan peningkatan filtrasi cairan transvaskular. Peningkatan tekanan hidrostatik kapiler paru biasanya disebabkan oleh meningkatnya tekanan di vena pulmonalis yang terjadi akibat meningkatnya tekanan akhir diastolik ventrikel kiri dan tekanan atrium kiri. Gambaran klinis edema paru kardiogenik yaitu adanya sesak napas tiba-tiba yang dihubungkan dengan riwayat nyeri dada dan adanya riwayat sakit jantung. Edema paru kardiogenik merupakan salah satu kegawatan medis yang perlu penanganan medis secepat mungkin setelah ditegakkan diagnosis. Penatalaksanaan utama meliputi pengobatan suportif yang ditujukan terutama untuk mempertahankan fungsi paru (seperti pertukaran gas, perfusi organ), sedangkan penyebab utama juga harus diselidiki dan diobati segera bila memungkinkan. Prinsip penatalaksanaan meliputi pemberian oksigen yang adekuat, restriksi cairan, mempertahankan fungsi kardiovaskular. Pertimbangan awal yaitu evaluasi klinis, EKG, foto toraks dan AGDA.Kata kunci: edema paru kardiogenik akut, tatalaksana

Latar belakang: Gagal jantung kronik merupakan penyakit progresif lambat dengan morbiditas serta mortalitas yang tinggi; penggunaan obat-obatan seringkali tidak berhasil memperbaiki hasil keluaran. Enhanced external counterpulsation (EECP) bersifat non-invasive dan merupakan alternatif terapi dalam penanganan gagal jantung. Penelitian ini bertujuan menilai pengaruh EECP terhadap myeloperoksidase (MPO) sebagai penanda inflamasi, dan pada keluaran klinis. Metode: Penelitian ini menggunakan desain uji klinik terkontrol secara randomisasi terbuka terhadap 66 penderita gagal jantung kronik pada Januari-Desember 2012. Pasien dibagi dalam dua kelompok: kelompok yang menjalani terapi EECP (n = 33) dan yang tidak menjalani terapi (non-EECP) (n = 33). Pemeriksaan MPO dilakukan pada awal dan setelah 6 bulan pengamatan. Selain itu juga dinilai kejadian kardiovaskular. Uji t tidak berpasangan digunakan untuk membandingkan kadar MPO dan uji chi-kuadrat untuk analisis kejadian kardiovaskular.