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Serial appraisals of rheumatoid activity by the systemic and articular indexes, performed by seasoned observers on patients who were accustomed to this type of examination, show an interobserver variation no greater than interlaboratory variations in determinations made on stock samples for uric acid, albumin and hemoglobin. However, the variation found when medical students examined new patients was considerably higher. Interobserver variation was not significantly greater than intraobserver variation. The precision and sensitivity of the various items composing the indexes are compared.Evalutationes serial del activitate rheumatoide a base del indices generalisate e articular, executate per experte observatores in patientes accostumate a iste type de examine, monstra un variation inter le observatores non plus grande que le variation inter laboratorios in le caso de determinationes a base de specimens standard pro acido uric, albumina, e hemoglobina. Tamen, le variation trovate quando studentes de medicina examinava nove patientes esseva considerabilemente plus alte. Le variation inter observatores non esseva significativemente plus grande que le variation intra le corpore de observationes del mesme observator. Es comparate le precision e le sensibilitate del varie componentes in le indices. METHOD FOR EVALUATING the inflammatory activity of rheuma-

The Systemic and Articular Indexes of Lansbury were utilized in a study of the effects of amodiaquin on 29 patients with rheumatoid arthritis. Significant beneficial effects were demonstrated when the drug was administered over a period of several months. Toxic effects of this agent are emphasized.Le indices systemic e articular de Lansbury esseva utilisate in un studio del effectos de Amodiaquina in 29 patientes con arthritis rheumatoide. Significative eff ectos benefic esseva demonstrate quando le droga esseva administrate durante un periodo de plure menses.Es sublineate le effectos toxic de iste agente.N THE LAST eight years, several synthetic antimalarial compounds1*

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