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Objectives: The aim of this study is to evaluate the GLUT-1 expression in benign proliferative, hyperplastic, and malignant endometrial tissues, to evaluate the usefulness of GLUT-1 expression in endometrial hyperplasia, and to determine its role in the neoplastic progression to endometrioid type adenocarcinoma. We also aimed to analyze some prognostic clinical parameters (age, stage, grade). Methods: This cross sectional study was carried out on paraffin embedded surgical specimens of endometrial tissue. Applying the immune histochemical techniques by using the GLUT-1 as a primary antibody, statistical analysis was done and the correlation with different clinical and pathological parameters were assessed. Results: 98 cases of endomertial tissue, 17.4% disordered proliferative endometrium, 22.4% endometrial hyperplasia without atypia, 18.4% endometrial hyperplasia with atypia, 41.8% endometrioid adenocarcinoma, 56.1% were GLUT-1 positive. Significant correlation was found between GLUT-1 expression and increasing degree of atypia as it was negative in benign proliferative and hyperplasia without atypia meanwhile positive in hyperplasia with atypia and endometrioid carcinoma. Significant correlation with grade of carcinoma, patient age, no correlation was found with ovarian and cervical metastasis, no significant correlation was found with tumor stage. Conclusions: GLUT-1 immunostaining may be useful in distinguishing hyperplasia without atypia from hyperplasia with atypia; GLUT-1 overexpression is a consistent feature of endometrioid adenocarcinoma.

Background: Up to 20% of human population is asymptomatic carriers for Staphylococcus aureus .Human nares colonized with Staphylococcus aureus are the most important reservoir of this pathogen and the carrier state affected by different variables. Aim: To investigate the influence of using oral hormonal contraceptive pills on Staphylococcus aureus nasal carriage state. Method: A cross sectional studies involved 125 Healthy woman who divided into two groups as users of hormonal contraceptives (60 women) and none or ever users (65 women). Cotton swab obtain from anterior nares of each woman and subjected to culture to identify the Staphylococcus aureus. The results were compared between the two groups. Pregnant woman and those who are immune-compromised, having chronic diseases and currently on antibiotic therapy were excluded from this study. Results: Staphylococcus aureus nasal carriage state was doubled in woman using oral hormonal contraceptives. This was correlated with the duration of use of this contraceptives, the longer the duration the more the carriers. Conclusion: Hormonal contraceptive pill may boost the risk of Staphylococcus aureus nasal carriage in healthy women