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Satna (M.P.) India, during 2016-17 and 2017-18 to study the response of different mango cultivars viz. Bombay Green, Dashehari and Langra to various chemicals namely potassium nitrate, potassium di-hydrogen orthophosphate, di-potassium hydrogen orthophosphate. The results of the experiment revealed that the per cent of bud swelling, panicle emergence and flowering shoot and length of panicle were higher with application of KH 2 PO 4 -1%+KNO 3 -1%. In case of cultivars, mango cv. Langra produced lengthier panicle than Bombay Green and Dashehari in both treated and untreated trees. Significantly narrowest sex ratio and higher number of hermaphrodite flowers, fruit set, fruit retention per panicle and number of fruits per tree were recorded with application of KH 2 PO 4 -1%+KNO 3 -1% treatment. In case of mango cultivars the narrowest sex ratio and higher number of hermaphrodite flowers, fruit set per panicle and number of fruit per tree were observed with Langra.

Background: Fenchone is a natural monoterpene abundantly present in Fennel essential oil. It is known for its wound healing properties but its other biological activities are less explored. Methods: We use an in silico structural similarity searching approaches to identify various biological activities of Fenchone. The identified biological activities of Fenchone (purchased from Sigma Aldrich) were validated by conducting DPPH free radical scavenging assay, MTT assay, well diffusion assay for antimicrobial activity and enzymatic assays to analyze the activity of different antioxidant enzymes. Results: Camphor was found to possess maximum structural similarity with Fenchone (similarity-index 100). Molecular docking demonstrates that binding modes of the Fenchone were also similar to Camphor against protein Cytochrome CYP101D1 (PDB ID: 4C9K). Fenchone was also demonstrated to possess antioxidant activity (IC50: 3.32±0.008mM), antimicrobial activity (MIC: 0.49mM) and a very strong antifungal activity. Fenchone protects yeast cells from H2O2 induced cytotoxicity and cytotoxic to cancerous Hela cells (IC50: 12.63±0.12 ΜM). Fenchone treatment also showed decreased activity of antioxidant enzymes Glutathione-S-transferase, Catalase and Lipid Peroxidase. Conclusion: To best of our knowledge this is first report which use structural similarity searching to explore biological activities of Fenchone.

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