Objective: This study aims that oxidative stress and inflammation status in children and adolescents with attention deficit hyperactivity disorder (ADHD) compared to their healthy peers. Method: Thirty ADHD and healthy controls were included in this study. ADHD diagnosis according to the DSM-V and Conners’ teacher and parent rating scale by a structured psychiatric interview. Total oxidant status (TOS), total antioxidant status (TAS), and total and native thiol levels were determined using photometric methods. Presepsin, Interleukin (IL) 1-ß, IL-6, and Tumor Necrosis Factor-alpha (TNF-α) levels were measured with commercial ELISA kits. Results: We showed that TOS and oxidative stress index were significantly higher in the ADHD group, and TAS was lower than in the control group ( p<.001). Similarly, IL1-ß, IL-6, and TNF-α levels were statistically higher in the ADHD group. Backward LR regression analysis reveals that TOS and IL-6 predicted ADHD. Conclusion: TOS and IL-6 levels may play a role in the pathogenesis of ADHD.
Yaygın eğitim kişilerin toplumsal değişimlere uyumunu sağlamak ve ulusal kalkınma hedeflerine ulaşmak için yaşam boyu eğitim felsefesi çerçevesinde yapılan tüm eğitim faaliyetleridir. Bunlar içinde yaygın din eğitimi resmi olarak Diyanet İşleri Başkanlığı eliyle yürütülen faaliyetlerdir. Özellikle yaygın din eğitimine katılan yetişkinlerin önemli bölümü kadınlardan ve bu eğitimi verenlerin de önemli kısmı kadın Kur'an kursu öğreticilerinden oluşmaktadır. Kur'an kursları aynı zamanda kadınların sosyalleşmesi için de önemli bir görev ifa etmektedir. Yaptığımız bu çalışmada yaygın din eğitimi veren Kur'an kurslarındaki öğreticilerin meslekî doyum düzeyleri ile bunlara etki eden değişkenlerin tespit edilmesi amaçlanmıştır. Çalışma nicel araştırma yöntemine göre yapılmıştır. Bu araştırmada Kuzgun, Sevim ve Hamamcı tarafından geliştirilen Meslekî Doyum Ölçeği kullanılmıştır. 2019 yılında, İstanbul Sancaktepe ve Kartal ilçelerinde çalışan Kur'an kursu öğreticileri araştırma kapsamına alınmıştır. Araştırma sonucunda öğreticilerin meslekî doyum düzeylerinin tam olduğu ortaya çıkmıştır. Kur'an kursu öğreticilerinin tam düzeyde bir mesleki doyum düzeyine sahip olmalarının temel sebeplerinden biri olarak, yapılan işin niteliğinin, manevi yönünün ve toplumdaki itibarının etkisi olduğu söylenebilir. Öğreticilerin doyum düzeylerine etki eden değişkenler arasında medeni durum, eğitim durumu ve sınıflarında okuttukları öğrenci sayıları yer almaktadır. Meslekî gelişim imkânlarına sahip olmanın, öğreticilerin mesleki doyumları üzerinde önemli etkisinin olduğu görülmüştür.
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder that affects 5% to 12% of children worldwide. Etiological factors, including nutrition, are involved in this disease, which is characterized by inattention, impulsivity, and hyperactivity symptoms. Fats, which form an important part of the daily diet, can have effects on ADHD and its symptoms. In the literature, it is stated that omega-3 fatty acids are low in children with ADHD, and supplementation studies may be effective in improving symptoms. In addition, high omega-6/omega-3 fatty acids ratio in the diet and diets rich in saturated and trans fatty acids are associated with ADHD. In this review, the relationship between ADHD and dietary fatty acids will be evaluated.
Objectives: Apigenin and parthenolide as natural products have potent antioxidant and anti-inflammatory outcomes that could make them a perfect option for endometriosis therapy. This study aimed to determine the effects of apigenin and parthenolide on created endometrial implants in a rat model of endometriosis. Methods: Thirty-nine mature, female Sprague-Dawley rats were assigned randomly to six experimental groups four weeks after endometriosis induction. Group 1 (n = 5): Control (CTRL) that opened and closed the abdomen; Group 2 (n = 6): Peritoneal and ovarian endometriosis (POE) + drug-free; Group 3 (n = 7): POE+ Apigenin (APG) (50 mg/kg); Group 4 (n = 7): POE+ Parthenolide (PTL) (10 mg/kg); Group 5 (n = 7): POE+ Apigenin (APG) (50 mg/kg) + Parthenolide (PTL) (10 mg/kg); Group 6 (n = 7): POE+ DMSO. An endometriosis model was created, and histopathological analysis and biochemical evaluation were performed. Serum and peritoneal levels of pro-and-anti-inflammatory cytokine, and oxidative stress of implant tissue were measured. Results: Serum IL-37 levels decreased significantly in the APG-treated group compared to the drug-free group (p = 0.016). The peritoneum and ovary endometriosis histopathologic scores were significantly lower in APG-treated (p = 0.001) and PTL-treated (p = 0.001) groups in comparison to the drug-free group. The oxidative stress index (OSI) values were increased statistically significantly in ovary endometriosis tissue in the drug-free group, (p = 0.001). However, compared to the drug-free group, OSI values decreased statistically significantly in the APG-treated group (p = 0.003). Conclusions: The application of apigenin caused a decrease in oxidative stress and an improvement in histopathological grade. Apigenin may be a novel therapeutic agent for the treatment of endometriosis.
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