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The study was conducted to evaluate the phytochemical, safety profile, analgesic, and anti-inflammatory effects of A. fistulosum. Fifty mice were divided into 5 groups randomly to determine the analgesic activity by using the tail-flick method and hot plate method respectively. Normal saline 5 ml/kg was given to group 1 orally whereas A. fistulosum was administered orally to groups 2, 3, and 4 at a dose of 200, 400, and 600 mg/kg respectively. Aspirin 300 mg/kg was given orally as a standard drug to a group of 5 animals. Acetic acid-induced writhing test were carried out in mice to evaluate peripheral analgesic activity. Animals were divided into 5 groups. Group1 act as a control group. Group 2 received Diclofenac Sodium whereas group 3, 4 and 5 received 200mg/kg, 400mg/kg and 600mg/kg of ethanol extract of A.fistulosum respectively. An anti-inflammatory effect was carried out on 50 rats. 1% carrageenan was used to induce edema in the paw. Group 1 acted as a control group whereas the other three groups received A. fistulosum at a dose of 200, 400, and, 600 mg/kg. The fifth group was given the standard drug Ibuprofen. The phytochemical evaluation was performed to reveal the constituents present in the ethanol extract of A. fistulosum. The screening demonstrates that pharmacologically active components such as flavonoids, carbohydrates, amino acids, glycosides, phenols, and tannins were present. The increase in latency period has been seen in all three groups of animals receiving A. fistulosum which shows an analgesic effect. The paw thickness of animals treated with ethanol extract at all three doses was also found to be significantly reduced. The safety profile of A. fistulosum was accessed by Lorke’s method which was found safe at the treated dose. In conclusion, the study shows the analgesic and anti-inflammatory effects of Ethanol extract of A. fistulosum, which was predominantly attributable to the presence of phytochemical compounds like flavonoids.

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Diuretics are efficaciously used in management of various clinical emergencies like hypertension, heart failure, cirrhosis, hypercalciuria, hematuria and nephrotic syndrome. Cymbopogon jwarancusa is an aromatic perennial grass used in both traditional and Unani system of medicine to eradicate diseases like colds, seasonal fever, asthma, tuberculosis, rheumatic pain, back pain, toothache and nervous disorders. C. jwarancusa essential oils are used in perfumery, soap, detergents, medicines and pharmaceutical industry. Monoterpenes and sesquiterpenes constitute the highest composition in essential oil of C. jwarancusa. The present was designed to compare the diuretic activity of C. jwarancusa after single and multi-doses. Furosemide (20 mg/kg) was used as reference drug and 10% DMSO was used as vehicle. Diuretic activity was noticed by measuring urine volume and calculating diuretic and Lipchitz values. Maximum diuretic response was observed at 500 mg/kg of extract after both single and multi-dose administration. On basis of results it may be concluded that C. jwarancusa may be used as diuretic agent.