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Experimental virus myocarditis was induced after subjecting 12–14-month-old albino mice (strain AB × A Jax) to physical exercise (swimming), and infection with Coxsackie virus A9 strain Lerner No. 13. Virus could be isolated from the hearts of infected mice. On day 3 post infection, 94%, and on day 6, 91% of the isolates were positive. If compared to non infected mice, the activity of plasma creatine kinase of infected animals rose considerably. It is suggested that the accelerated release of the enzyme from the heart muscle is due to a decrease in cell membrane stability following virus-cell interaction. Whether or not infection and damage of cardiac muscles has taken place can thus be determined by measuring plasma creatine kinase activity.