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Antibody-dependent cellular cytotoxicity (ADCC) against human erythrocytes was investigated in 39 type I and 63 type II diabetic patients in comparison to 177 healthy blood donors. The cytotoxic capacity of lymphocytes from diabetics was significantly increased. The highest values were measured in insulin-treated type II diabetics (after secondary failure of a previous sulfonylurea therapy).--It is suggested that in certain cases of type II diabetes an increased unspecific K cell-and/or antibody-dependent cellular cytotoxicity plays a pathogenetic role in the development of the disease. The latter might possibly be directed against insulin receptors.

The case of a 57‐year‐old woman with the diagnosis of angioimmunoblastic lymphadenopathy (AILD) is reported. During the 15 years of the disease, no malignant transformation had been detected. The clinical picture is unusual in certain respects. Lymph node manifestation had been preceded by extraglandular AILD infiltrates. All histologic materials showed a picture typical of AILD. A functional study of peripheral lymphocyte subpopulations revealed decreased natural cytotoxicity and decreased T‐lymphocyte activity.