The findings of increased proliferation rate in goitres with an aneuploid or neoplastic component suggests that some factors involved in goitrogenesis could also be responsible for the development of chromosomal aberrations and/or for the selection of cellular clones endowed with high growth potential.

The authors used nuclear DNA analysis to evaluate 142 patients with bladder tumours in stage Ta, T1. During follow-up, only the T1G2-G3 forms progressed. Tumour stage and DNA Index (DI) > 1.25 were strongly correlated to tumour invasiveness. According to these data, patients with tumours in the T1 stage and Dl>1.25 should undergo closer follow-up.