We present a theory of the high-spin generalization of topological insulators and their doped superconducting states. The higher-spin topological insulators involve a pair of J = 3/2 bands with opposite parity, and are characterized by their band inversion. The low-energy effective theory reveals that the topological insulators host four different phases characterized by mirror Chern numbers, at which boundaries two different patterns of bulk Dirac points appear. For the carrierdoped case, it is shown that the system may host unique unconventional superconductivity because of its high-spin nature and additional orbital degrees of freedom intrinsic to topological insulators. The superconducting critical temperature is evaluated by using density-density pairing interactions, and odd-parity Cooper pairs are shown to be naturally realized in the presence of interorbital pairing interaction. It is observed that even the simplest spin 0 odd-parity pairing state exhibits a novel class of topological superconductivity-high winding topological superconductivity. We also discuss the experimental signals of high winding topological superconductivity in the case of the antiperovskite superconductor Sr3−xSnO.

These results suggest that the early increase in mesenteric lymph flow rate in guinea pigs produced by LPS is mediated by vascular hyperpermeability and plasma albumin leakage.

Lipopolysaccharide (LPS) is thought to be the causal agent of paralytic ileus in sepsis. We have reported that contraction of taenia caecum isolated from guinea pigs is suppressed by LPS. In the present study, we tried to create a new experimental method for the study of intestinal paralysis induced by LPS with continuously recorded changes in the movement of taenia caecum of conscious guinea pigs. Laparotomy was performed under pentobarbital anesthesia in guinea pigs, and a microforce transducer was sutured on taenia caecum. After operation, the guinea pigs were allowed to eat and drink freely. Four days later, LPS (E. coli, O111:B4) was injected into the abdominal cavity, and the movement of taenia caecum was recorded. Changes in body temperature after the administration of LPS were measured successively. Intestinal contraction movements in conscious guinea pigs were recorded in a stable manner for many hours. The characteristic relaxing action of taenia caecum was that it peaked between 2 and 4 hours after administration of LPS and that it was dependent on the LPS-dose. Body temperature changed in good correlation to the tension of taenia caecum. The above results suggest that the novel method, monitoring the intestinal movement of conscious guinea pigs, is a useful experimental model for the study of intestinal paralysis due to endotoxicosis. (JJAAM 2003; 14: 241-50)

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Cannabinoids decreased intestinal tract tension in vivo, apparently via central CB1 receptors. This differs from peristaltic suppression.