In clinically hyperthermia and irradiation therapy for malignant neoplasms are known that they have antiproliferative activity and cell death (including apoptosis) inducing activity. However not only mechanisms of cell death induction but treatment effects of them still have been unclear. In this time we showed that cell cycles from G0/G1 phase to S-G2/M phase were delayed by hyperthermia and G2/M phase accumulation were caused immediately by irradiation. And we also demonstrated that the combination treatments of hyperthermia and irradiation induced synergistic antiproliferative effects and strong effects of cell death to human esophageal carcinoma cell lines. Although treatments of hyperthermia and irradiation were mild individually, combination treatment of hyperthermia and irradiation were useful for esophageal carcinoma treatment.

No abstract

No abstract

2)We report a case of Paget-type recurrence 10 years after breast-conserving therapy. The patient was a 51-year-old woman who, at first surgery, had undergone quadrantectomy and axillary dissection with radiotherapy for non-invasive ductal carcinoma of the left breast. An erythematous lesion appeared in the ipsilateral nipple-areolar region 10 years after the first surgery. Skin biopsy revealed that it was a Bowen's disease-like lesion associated with no lesion in the breast. She underwent local excision involving the subdermal and mammary tissue under the skin lesion. Postoperative pathohistological examination revealed Paget-like cells in the epidermis and ductal carcinoma in situ in the nipple. The tumor cells were positive for CK7 and HER2 but negative for CK20, ER, PgR, and GCDFP15 by immunohistochemical study. We concluded that it was Paget-type recurrence 10 years after breastconserving therapy. She received adjuvant chemotherapy and no recurrent lesion has been detected.