Super paramagnetic iron oxide (SPIO) is taken up in the bone marrow and lymph nodes, as well as by the liver. Focusing on the intervertebral disks, which are unaffected by contrast effects, we examined the relationship between magnetic resonance image (MRI) signal intensity after SPIO uptake in the vertebral body and intervertebral disks and investigated MRI signal intensity in bone marrow metastases and osteomyelitic (inflammatory) lesions after SPIO uptake by bone marrow. The lumbar spine was imaged in 5 healthy volunteers (age range, 26-48 years). A specified amount of SPIO was administered intravenously, and signal intensities before and after administration were measured. The signal intensity ratio with respect to the value before administration was calculated, and quantitative signal analysis was conducted. A similar investigation was performed in patients with bone metastasis and osteomyelitis. As a result of the metastasis, the signal intensity ratio showed a low value in comparison with normal marrow, and the osteomyelitis showed a high value in comparison with normal marrow. We report the usefulness of evaluations of changes in marrow signal intensity using SPIO in MRI.
Inorganic chemistry Z 0100 Magnetic Resonance Study of Nanodiamonds -[22 refs.]. -(SHAMES, A. I.; PANICH, A. M.; KEMPINSKI, W.; BAIDAKOVA, M. V.; OSIPOV, V. Y.; ENOKI, T.; VUL, A. Y.; NATO Sci. Ser., II 192 (2005) 271-282; Dep. Phys., Ben-Gurion Univ. Negev, Beer Sheva 84105, Israel; Eng.) -Schramke 05-244
In proton magnetic resonance (MR) spectroscopy ( 1 H-MRS) of the breast cancer, choline peak could be detected. The purpose of this study was to evaluate the influences of the tumor volume, full width at half maximum (FWHM) of the water peak (FWHM), and T2* value of water (T2* value) on the detection rate of the choline peaks at 3.0 T-MRI. We measured FWHM and T2* value in 109 cases, and we evaluated the effect of tumor volume on the detection rate of the choline peaks and the effect of FWHM and T2* value on the detection of choline peaks. In 1 H-MRS of breast cancer at 3.0 T-MRI, the detection rate of the choline peaks improved as the tumor volume was larger. As a shimming environment when acquiring 1 H-MRS of breast cancer, FWHM is preferably 57.4 Hz or less and T2* value should be 11 ms or more, and T2* value has a great influence on the detection rate of the choline peaks.
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