Aim: This study was designed to assess the effect of vitamin E supplement on Creatine Kinase (CK-MB) C - reactive protein, (C-RP), urea and creatinine of albino rats fed with high fat diet. Methodology: A total of twenty (20) albino rats of both sexes were used in this study. They were grouped into four (4) groups comprising of five (5) rats each. Group 1 was fed with normal diet; group 2 with normal diet and treated with vitamin E supplement (70 mg/kg); group 3 was fed with high fat diet only, while group 4 was fed with high fat diet and treated with vitamin E supplement (70 mg/kg). The treatments were administered daily using oral gavage method for a period 21 days. After the experimental period, the animals were sacrificed and blood samples collected for the analysis of CK-MB, CRP, urea and creatinine respectively using ELISA and colorimetric method with a spectrophotometer. Data generated were analyzed statistically using SPSS version 20 and P = 0.05 was considered statistically significant. Results: The results revealed a significance difference in C-RP (mg/l) levels (P < 0.001) amongst the groups with a decreased C-RP levels in group 2 (1.43 ± 0.39) compared to group 1 (1.94 ± 0.53), then in group 4 (2.27 ± 0.53) which is also decreased compared to group 3 (3.31 ± 0.63). For CK-MB  there was also a significant difference among the different groups. In group 2, it was 1.94 ± 0.65 ng/ml which was decreased compared to group 1 (2.22 ± 0.55), and group 4 (2.74 ± 0.68) compared to group 3 (3.31 ± 0.62). For the urea and creatinine results, there was no significant difference (p > 0.05) among the groups when the mean levels were compared. Conclusion: This shows that administration of vitamin E to rats fed normal or high fat diet could significantly reduce the plasma levels of CRP and CK-MB hence having some ameliorative effects on high fat induced inflammatory and cardiovascular risks or conditions.

Gravidity, or the number of pregnancies a woman has had, is linked to a number of biochemical alterations, including changes in cardiovascular parameters. These modifications may increase the likelihood of cardiovascular disease in this population. The aim of this research was to evaluate the effect gravidity has on some cardiovascular markers among normotensive pregnant women. A cross-sectional study of 100 women of reproductive age was carried out at Rivers State University and Rivers State University Teaching Hospital, the subjects were chosen at random for the study. Blood samples were taken and tested for total cholesterol, triglycerides, high density lipoprotein, uric acid, and Apolipoprotein A1 and B. Apolipoprotein A1 and B were all measured in blood samples for biochemical analysis. The levels of low density lipoprotein and very low density lipoprotein were determined. Graph Pad Prism Version 8.0.2.263 was used to analyze the data from the study. Result gotten from the study showed that Gravidity had no significant effect on biochemical parameters (TC, TG, UA, LDL, Apo A1, Apo B, CRP, and VLDL) in pregnant women (P>0.05), but there was a significant increase (P<0.05) in HDL levels among the group; 0.87 ± 0.21 (1-2), 0.93 ± 0.21 (3-4), 0.86 ± 0.12(5-6) and 1.30 ± 0.00 for (7-8). The effect of gravidity (1-2, 3-4, 5-6, 7-8) on HDL was shown to be significant for ANOVA and Turkey post hoc multiple comparison test; (1-2 vs 7-8) (P= 0.0204) and (5-6 vs 7-8) (P= 0.0250).. This study demonstrated that gravidity had little or no effect on the biochemical parameters but increases the HDL cholesterol level in normotensive pregnant women.   

Introdction: Haematological parameters are useful in making diagnosis of diseases and also help in the antenatal assessment of women during pregnancy. The physiological changes of pregnancy, due to the influence of hormones such as oestrogen, progesterone also affect haematological indices when compared with the non-pregnant state. Aim: The study investigated haematological indices in pregnant women with plasmodiasis attending antenatal clinics in Primary health care centre Ozuoba, Port Harcourt. Methodology: This was a cross sectional study, which recruited a total of one hundred (100) subjects, of which (40) were non parasitized pregnant women who served as control, while (60) were parasitized pregnant women who served as test. The samples were analyzed for haematological parameters using (Sysmex XP-300), while microscopy was used to investigated for the presence of malaria parasite. Result: Comparing the hematological parameters of the study population at different level of plasmodiasis, showed that WBC, and Neutrophil were significant with p-Value of 0.001 and 0.0089 respectively at P<0.05. The other haematological parameters such as, Red Blood Cell, Haemoglobin, Haematocrit, Mean Cell Volume, Mean Cell Haemoglobin, Mean CellHaemoglobin Concentration, Platelet, Plateletcrit, Neutrophils, lymphocyte, monocyte, eosinophil and basophil showed no statistical significant difference at p<0.05. While comparison of the haematological parameters of the study group according to parity showed that WBC count had statistical significance with a p-Value of 0.0035 at p<0.05. Conclusion: Findings from this study has shown that there was statistical significant difference in the white blood cell count of malaria-parasitized pregnant subject. It was further revealed that there was no statistical significant difference in the other haematological parameters. The reason for the pattern of result obtained is that some of the pregnant women may have been receiving prophylactic antimalarial drugs before their recruitment, this will in turn minimize the impact of malaria infection on some haematological parameters.