Solanum nigrum, a medicinal plant, traditionally used in treating diabetes mellitus. In this study, we used the leaf extract of the plant to synthesize silver nanoparticles (AgNPs), as a proposition to treat alloxaninduced diabetic rats. The phytosynthesised AgNPs were analyzed using UV-visible and Fourier transform infra-red spectroscopy for their functional groups. Transmission electron microscopy revealed that, the synthesized particles are found to be 4-25 nm in size. Monodispersed and spherical nature of synthesized AgNPs were shown by scanning electron microscope and the presence of Ag in the AgNPs was confirmed by energy dispersive spectrum. The phytosynthesised AgNPs were evaluated for its antidiabetic activity in alloxan-induced diabetic rats. AgNPs-treated diabetic rats found to be significantly improved the dyslipidemic condition as seen in the diabetic control. Furthermore, it also reduced the blood glucose level over the period of treatment. The improvement in body weight was also found to be evidence for S. nigrum extract-mediated AgNPs as a potential antidiabetic agent against alloxaninduced diabetic rats.
In the present study, we have reported an eco-friendly, rapid, and simple method for the synthesis of silver nanoparticles (AgNPs) using Bauhinia purpurea flower extract as non-toxic bioreducing agent. The formation of AgNPs was confirmed by UV-visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy and energy-dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). The synthesized AgNPs were spherical in shape with an average size of 20 nm. Furthermore, the antibacterial activities of the synthesized AgNPs (2-10 mM) against clinical pathogens, Klebsiella sp. and Staphylococcus sp., were evaluated under in vitro conditions.
A rapid, green phytosynthesis of silver nanoparticles (AgNPs) using the aqueous extract of
Helianthus tuberosus
(sunroot tuber) was reported in this study. The morphology of the AgNPs was determined by transmission electron microscopy (TEM). Scanning electron microscopy–energy-dispersive spectroscopy (SEM–EDS) and X-ray powder diffraction (XRD) analysis confirmed the presence of AgNPs. Fourier transform infrared spectroscopy (FTIR) analysis revealed that biomolecules in the tuber extract were involved in the reduction and capping of AgNPs. The energy-dispersive spectroscopy (EDS) analysis of the AgNPs, using an energy range of 2–4 keV, confirmed the presence of elemental silver without any contamination. Further, the synthesized AgNPs were evaluated against phytopathogens such as
Ralstonia solanacearum
and
Xanthomonas axonopodis
. The AgNPs (1–4 mM) extensively reduced the growth rate of the phytopathogens. In addition, the cytotoxic effect of the synthesized AgNPs was analyzed using rat splenocytes. The cell viability was decreased according to the increasing concentration of AgNPs and 67% of cell death was observed at 100 μg/mL.
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