Fungal infections remain a major determinant of survival in CGD. X-linked patients generally had more severe disease, and this was generally in those with lower residual superoxide production. Survival in CGD has increased over the years, but infections are still major causes of morbidity and mortality.

The synthesis and characterization of a stable, acyclic two-coordinate silylene, Si(SArMe6 )2 [ArMe6 = C6H3-2,6(C6H2-2,4,6-Me3)2], by reduction of Br2Si(SArMe6 )2 with a magnesium(I) reductant is described. It features a V-shaped silicon coordination with a S–Si–S angle of 90.52(2)° and an average Si–S distance of 2.158(3) Å. Although it reacts readily with an alkyl halide, it does not react with hydrogen under ambient conditions, probably as a result of the ca. 4.3 eV energy difference between the frontier silicon lone pair and 3p orbitals.

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The synthesis, spectroscopic and structural characterization of an extensive series of acyclic, monomeric tetrylene dichalcogenolates of formula M(ChAr)2 (M = Si, Ge, Sn, Pb; Ch = O, S, or Se; Ar = bulky m-terphenyl ligand) are described. They were found to possess several unusual features-the most notable of which is their strong tendency to display acute interligand, Ch-M-Ch, bond angles that are often well below 90°.Furthermore, and contrary to normal steric expectations, the interligand angles were 2 found to become narrower as the size of the ligand was increased. Experimental and structural data in conjunction with high-level DFT calculations, including corrections for dispersion effects, led to the conclusion that dispersion forces play a key role in stabilizing their acute interligand angles.

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