MATSUMOTO, TAMAKI, CHIEMI MIYAWAKI, HIDETOSHI UE, TOMO KANDA, YASUHIDE YOSHITAKE, AND TOSHIO MORITANI. Comparison of thermogenic sympathetic response to food intake between obese and non-obese young women. Obes Res. 2001;9:78 -85. Objective: Sympathetic nervous system abnormality in humans is still a matter of debate. The present study was designed to examine diet-induced autonomic nervous system activity and metabolic change in obese and non-obese young women. Research Methods and Procedures: Sixteen age-and height-matched obese and non-obese young women participated in this study. Sympathovagal activities were assessed by means of our newly developed spectral analysis procedure of heart-rate variability during the resting condition and after mixed-food ingestion (480 kcal). Energy expenditure was also measured under these two conditions. Results: There was no significant difference in any of the parameters of the heart-rate variability between the obese group and control group during the resting condition. In the control group, both absolute values (221.5 Ϯ 54.5 vs. 363.8 Ϯ 43.7 ms 2 , p Ͻ 0.05) and relative values (0.23 Ϯ 0.03 to 0.36 Ϯ 0.02, p Ͻ 0.05) of a very-low-frequency component and global sympathetic nervous system index (1.46 Ϯ 0.19 vs. 3.26 Ϯ 0.61, p Ͻ 0.05) were significantly increased after mixed-food ingestion compared with the values obtained after resting condition. However, no such sympathetic response was found in the obese group. Energy expenditure increased in the two groups after the meal, but the magnitude of the increase above the preprandial resting condition was significantly greater in the control group than in the obese group (11.2 Ϯ 2.3 vs. 6.7 Ϯ 0.8%, p Ͻ 0.05). Discussion: Our data suggest that despite identical sympathovagal activities at the resting condition, obese young women may possess a reduced sympathetic response to physiological perturbation such as mixed food intake, which might be related to lowered capacity of thermogenesis and the state of obesity.

Twelve weeks of exercise training has significantly improved both the sympathetic and parasympathetic nervous activities of the obese individuals with markedly reduced ANS activity, suggesting a possible reversal effect of human ANS functions. These favorable changes may also have an influence on the thermoregulatory control over the obesity.

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Dietary intakes of soy protein (at least 20 g) and isoflavones (at least 80 mg) for 5 weeks would be effective in reducing CHD risk among high-risk, middle-aged men.

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