Background<br />Anemia is a frequent complication of chronic kidney disease (CKD). Anemia in CKD is associated with reduced quality of life, increased cardiovascular disease, cognitive impairment, and mortality. Therefore it is necessary to find an alternative agent for preventing anemia in CKD. Celery is one of the natural substances that have anti-inflammatory, antioxidant, and antihypertensive pharmacological effects. Based on the mechanism of CKD and its progression, celery is thought to prevent anemia in CKD. This research was aimed at evaluating the protective effect of celery extract against anemia in a CKD rat model. <br /><br />Methods<br />This was an experimental laboratory study using 25 male Sprague Dawley rats, aged 2-3 months, they were randomized into 5 groups, namely group A, sham operation; group B, subtotal nephrectomy; group C, D, E, subtotal nephrectomy + 250, 500, 1000 mg/kg BW ethanol extract of celery, respectively. The administration of celery extract was performed 14 days before and 14 days after induction of 5/6 subtotal nephrectomy. The hematological parameters (Hb, RBC, Ht, MCV, MCH, MCHC) and serum creatinine level were measured at the end of the study. Data were analyzed with One Way ANOVA and Kruskal-Wallis test followed by Mann-Whitney test at p&lt;0.05. <br /><br />Results<br />There were no significant differences between groups in Hb, RBC, Ht, MCV (p&gt;0.05) and significant differences between groups in MCH and MCHC (p&lt;0.05). The highest levels of Hb, RBC, and Ht were found in group C.<br /><br />Conclusion<br />Celery ethanol extract at a dose of 250 mg/kg BW/day may prevent anemia in the CKD rat model.

Latar Belakang : Diabetes Melitus (DM) atau disingkat diabetes adalah gangguan  kesehatan  yang berupa  syndrom  yang  disebabkan  oleh  peningkatan kadar gula (glukosa) darah akibat kekurangan ataupun resistensi insulin. Di Puskesmas Pematang Kandis di dapatkan jumlah penderita diabetes melitus sebanyak 38 penderita. Tujuan Penelitian : diketahuinya faktor- faktor pada penderita diabetes melitus yang berhubungan terhadap terjadinya penyulit DM pada penderita DM di Wilayah Kerja Puskesmas Pematang Kandis Bangko.Metode Penelitian: Jenis penelitian ini menggunakan pendekatan kuantitatif dengan rancangan cross sectional. Penelitian ini dilakukan di Wilayah Kerja  Puskesmas  Pematang  Kandis  Bangko.  Populasi  dalam penelitian ini berjumlah 38 penderita DM dan semua populasi ditetapkan sebagai sampling (total sampling). Data dikumpulkan melalui wawancara dengan menggunakan kuisoner. Data dianalisis secara Bivariat dengan menggunakan uji chi-square pada tingkat kepercayaan 95% (p< 0,05).Hasil Penelitian: Menunjukkan ada hubungan antara pengetahuan (x2  = 6,8) dan sikap (x2  = 5,8)   dengan pencegahan penyulit DM

<p class="email"><strong>Background</strong></p><p class="email">Microalbuminuria is the earliest evidence of diabetic nephropathy and a major predictor of end stage renal disease (ESRD). The objective of the study was to determine the influence of several risk factors on the presence of microalbuminuria in type 2 diabetics.</p><p><strong> </strong></p><p><strong>Methods</strong></p><p>This observational cross-sectional study was done on 73 patients with type 2 diabetes, who attended the <em>Prolanis</em> program in Primary Health Care from May to November 2018. Detailed medical histories including duration of diabetes and relevant clinical examinations including fasting blood sugar (FBS), post-prandial blood sugar (PPBS), HbA1c, serum creatinine, blood urea and urinary microalbumin were recorded for each patient. A multiple regression analysis was used to analyze the data. The analysis was assessed at 5% level of significance.</p><p><strong> </strong></p><p><strong>Results</strong></p><p>Mean age of study population was 51.89 ± 6.78 years with female preponderance (51.1%). Mean FBS, PPBS, HbA1c, duration of diabetes, systolic blood pressure, microalbuminuria and serum creatinine was 182.51 ± 74.63 mg/dL, 186.25 ± 26.72 mg/dL, 8.8 ± 1.83%, 9.37 ± 5.96 years, 118.44 ± 4.13 mmHg, 30.32 ± 3.2 mg/day and 1.33 ± 0.64 mg/dL respectively. Duration of diabetes and HbA1c were positively correlated with microalbuminuria (β=0.052; Beta =0.367; p&lt;0.001 and β=0.058; Beta=0.363; p&lt;0.001) respectively.</p><p><strong> </strong></p><p><strong>Conclusions</strong></p><p>Duration of diabetes was the most important risk factor of microalbuminuria in type 2 diabetes patients. Therefore microalbuminuria can predict diabetic nephropathy earlier, as a warning to prevent further worsening of diabetic complications.</p><p class="fax"> </p>

A significant increase in the number of mental disorders has been a phenomenon in the world, including Indonesia. It may indicate by the increasing number of the inpatients of mental hospitals. The study aims to determine the effect of the combination of psychosocial therapy and vitamin C on the stress and immunity level of patients with mental disorders. This study applied pre-experimental design on three groups in which each group consists of seven respondents with an assumption that 20% will be lost of follow up. The sampling technique is purposive sampling. The criteria of the respondents include patients with schizophrenia, adults and administered with the same antipsychotic medication. The intervention includes the 500 mg of vitamin C and relaxation technique for four weeks on a daily basis. The stress levels and immunity of the patients are measured at the end of each month. One-way ANOVA is employed as the data analysis technique. The results of analysis in stress levels and immune responses between the three groups after the intervention of Vitamin C and relaxation techniques showed a mean difference in each group. The F value of 1.534 and an associated p value of 0.234 for stress levels, and f value of 0.790 with p value of 0.469 statistically indicate the insignificant difference between the three groups. Meanwhile, during the interview as an assessment of stress levels, the second and third intervention groups were more cooperative compared to the first group. Respondents were more cooperative during mental status examination after the end of the second and third weeks, and showed an improvement in CD4 immunity (cluster of differentiation 4).

Background: Adequate nutrition is one of the critical factors in the development process of pre-school age children. Regular consumption of fruit and vegetables can optimize nutrient intake so that growth and development run optimally. Unfortunately, consumption of fruits and vegetables in pre-school children is still low. This is due to a lack of knowledge about the types, benefits, and importance of fruits and vegetables. Objective: This study aims to prove the application of the storytelling method in optimizing the knowledge and consumption of fruits and vegetables in pre-school children in the city of Semarang. Methods: The design of this study used Experimental Quasy with pretest-posttest control group design. This research was conducted from September to November 2017 with a total sample of 120 respondents. Conclusion:The results showed that the application of storytelling affected increasing the knowledge and practice of eating fruits and vegetables at the age of pre-school children in ). Based on this, the application of storytelling can be used as an alternative method in conducting health education so that pre-school age children can consume fruits and vegetables.