Background<br />Anemia is a frequent complication of chronic kidney disease (CKD). Anemia in CKD is associated with reduced quality of life, increased cardiovascular disease, cognitive impairment, and mortality. Therefore it is necessary to find an alternative agent for preventing anemia in CKD. Celery is one of the natural substances that have anti-inflammatory, antioxidant, and antihypertensive pharmacological effects. Based on the mechanism of CKD and its progression, celery is thought to prevent anemia in CKD. This research was aimed at evaluating the protective effect of celery extract against anemia in a CKD rat model. <br /><br />Methods<br />This was an experimental laboratory study using 25 male Sprague Dawley rats, aged 2-3 months, they were randomized into 5 groups, namely group A, sham operation; group B, subtotal nephrectomy; group C, D, E, subtotal nephrectomy + 250, 500, 1000 mg/kg BW ethanol extract of celery, respectively. The administration of celery extract was performed 14 days before and 14 days after induction of 5/6 subtotal nephrectomy. The hematological parameters (Hb, RBC, Ht, MCV, MCH, MCHC) and serum creatinine level were measured at the end of the study. Data were analyzed with One Way ANOVA and Kruskal-Wallis test followed by Mann-Whitney test at p&lt;0.05. <br /><br />Results<br />There were no significant differences between groups in Hb, RBC, Ht, MCV (p&gt;0.05) and significant differences between groups in MCH and MCHC (p&lt;0.05). The highest levels of Hb, RBC, and Ht were found in group C.<br /><br />Conclusion<br />Celery ethanol extract at a dose of 250 mg/kg BW/day may prevent anemia in the CKD rat model.

Ischemia/ reperfusion injury (IRI) is marked by the sudden decrease of blood supply to the kidney followed by restoration of blood flow. Ischemic acute kidney injury (AKI) is the leading cause of morbidity and mortality. Therefore, the prevention strategy for decreasing the damage due to IRI is required. Celery (Apium graveolens L) is often consumed as food. Celery has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of the celery on kidney damage in the kidney ischemia/ reperfusion injury rat model.  Twenty-five rats male, 2-3 months old Sprague Dawley were divided into 5 groups: Group 1  was sham operation, group 2 was ischemia/ reperfusion injury (IRI), group 3, 4, 5 were IRI and 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW of ethanol extract of celery respectively for 14 days before and 3 days after operation. Blood serum sample was taken 3 days after the operation for measuring urea, creatinine, superoxide dismuthase (SOD) and nitrite oxide (NO). Hematoxylin-eosin (HE) staining was utilized to examine kidney tubular injury score. Data were analyzed using One-way ANOVA (p<0,05). The ethanol extract of celery at dose 1000 mg/kgBW prevented the increase of urea, creatinine serum, kidney tubular injury score and prevented the decrease of SOD, NO in the kidney ischemia/ reperfusion injury rat model (p<0,05). In conclusion, the ethanol extract of celery has a protective effect on kidney damage in the ischemia/ reperfusion injury rat model.

Hypertension and obesity are major risks factor for cardiovascular disease (CVD), which is one of the leading causes of mortality. Many studies have shown that body mass index (BMI) and mid-upper arm circumference (MUAC) measurements are associated with blood pressure in children and adults. However, the association has not been studied extensively in young men. This study aims to investigate the correlation between BMI with blood pressure and MUAC and MUAC with blood pressure in young men. This is a cross-sectional study that consisted of 38 male participants who met the criteria. Blood pressure, BMI, and MUAC were measured using standard procedures. The mean of BMI, MUAC, systolic blood pressure (SBP), and diastolic blood pressure (SBP) was 24.68±4.41 kg/m2, 30.23±5.45 cm, 117.39±10.47 mmHg, and 75.57±8.44 mmHg, respectively. The Pearson correlation test between the BMI with SBP and BMI with DBP was statistically significant (p≤0.05) with r=0.446 and r=0.537, respectively. Contrarily, the MUAC and blood pressure show no significant association. This study concluded a moderate positive correlation of BMI with systolic and diastolic blood pressure in young men subjects.

Chronic kidney disease (CKD) masih menjadi masalah kesehatan masyarakat di seluruh dunia. CKD terjadi akibat pengurangan nefron fungsional dan penurunan laju filtrasi glomerulus (GFR) sehingga terjadi penurunan fungsi ginjal yang akan menyebabkan gangguan dalam proses fisiologik ginjal, terutama dalam hal ekskresi zat-zat sisa termasuk asam urat. Laju filtrasi glomerulus ≤50% mulai terjadi peningkatan kadar kreatinin, urea, dan juga asam urat. Peningkatan asam urat akan terus bertambah seiring dengan penurunan (LFG). Perlu upaya untuk pencegahan progresifitas CKD. Salah satu upaya yang dapat dilakukan adalah dengan memanfaatkan bahan alam yaitu seledri. Seledri mempunyai efek sebagai sebagai anti inflamasi, antioksidan, antihipertensi dengan kandungan flavonoid, saponin, tanin 1%, minyak asiri, apiin, apigenin, kolin, asparagines, zat pahit, vitamin A, B, dan C. Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak etenol seledri terhadap kadar asam urat pada tikus model CKD. Sebanyak 25 ekor tikus putih dibagi dalam 5 kelompok. Kelompok 1: kontrol sham, kelompok 2: kontrol sakit, kelompok 3, 4, dan 5: kelompok 5/6 nefrektomi subtotal dan diberi ekstrak etanol seledri dosis 250, 500, dan 1000 mg/kgBB 14 hari sebelum dan 14 hari setelah pembuatan model 5/6 nefrektomi subtotal. Asam urat diperiksa menggunakan sampel serum darah. Data dianalisis dengan uji Kruskal-Wallis dilanjutkan dengan uji post hoc Mann Whitney dengan signifikansi p<0,05. Rerata kadar asam urat kelompok A: 0,618±0,044, B: 1,400±0,231, C: 1,394±0,112, D: 1,586±0,434, E: 1,632±0,212. Terdapat perbedaan bermakna rerata kadar asam urat antara kelompok A dibanding kelompok B, C, D, dan E. Kadar asam urat kelompok C lebih rendah dibanding kelompok B namun tidak berbeda signifikan, dan kadar asam urat kelompok D dan E lebih tinggi dibanding kelompok B. Pemberian ekstrak etanol seledri tidak dapat mencegah peningkatan kadar asam urat pada tikus model CKD.

No abstract