Cad. Saúde Colet., 2016, Rio de Janeiro, 24 (3): 376-383 376Hipertensão arterial e fatores associados em uma comunidade quilombola da Bahia, BrasilHypertension and associated factors in a community quilombola of Bahia, Brazil ResumoObjetivo: Determinar a prevalência da hipertensão arterial (HA) e investigar fatores associados em uma comunidade quilombola da Bahia, Brasil. Métodos: A HA foi determinada por autorreferimento de diagnóstico feito por um médico ou enfermeiro. Por meio de questionário, foram coletados dados demográficos, socioeconômicos, hábitos de vida e alimentares e presença de comorbidades. Foram realizadas medidas antropométricas e dosagens bioquímicas para determinação de sobrepeso/obesidade, diabetes e dislipidemias. Empregaram-se análise univariada para determinar associação entre HA e variáveis de interesse, e análise múltipla por regressão de Poisson para estimativa das razões de prevalência. Resultados: A população estudada foi de 213 indivíduos maiores de 18 anos. A prevalência de HA foi de 38,5%. Após análise ajustada, permaneceram associados à HA: sexo feminino, idade, menor escolaridade, maior renda per capita, uso de medicamentos nos últimos 15 dias, obesidade e diabetes mellitus. Conclusões: Os resultados evidenciam a necessidade de ações intersetoriais voltadas para a melhoria das condições de vida e saúde dessa comunidade. A adequação da infraestrutura e do funcionamento do serviço de saúde local, bem como a realização de campanhas de promoção da saúde, pode contribuir para a prevenção, diagnóstico precoce e tratamento da hipertensão e outros agravos. Palavras-chave: hipertensão; fatores de risco; comunidades vulneráveis; grupo com ancestrais do continente africano. AbstractObjective: To determine the prevalence of hypertension and investigate associated factors in a Quilombola community of Bahia (Brazil). Methods: Hypertension was based on diagnosis made by a physician or a nurse and self-reported by participants; demographic, socioeconomic, lifestyle, food habits, and comorbidities data were collected through a previously validated questionnaire. Anthropometric and biochemical measurements for overweight/obesity, diabetes and dyslipidemia were performed. Univariate and multivariable analysis using Poisson regression were conducted to estimate the association between hypertension and the variables of interest to estimate the adjusted prevalence ratios. Results: The study population comprised 213 individuals older than 18 years. The hypertension prevalence was 38.5%. In the adjusted analysis hypertension was associated with female sex, age, lower education, higher per capita income, use of drugs in the last 15 days, obesity, and diabetes mellitus. Conclusions: The results highlight the need for intersectorial actions to improve the community living conditions and health. The adequacy of local health service infrastructure and operation as well as health promotion campaigns can contribute to the prevention, early diagnosis and treatment of hypertension and other diseases.

1 perspective of structural changes and antigenicity of the Spike protein 2 The recent emergence of a novel coronavirus (SARS-CoV-2) is causing a severe 3 global health threat around the world characterized by severe acute respiratory 4 syndrome (Covid-19). At the moment, there is no specific treatment for this 5 disease and vaccines are still under development. The structural protein Spike is 6 essential for virus infection and has been used as the main target for vaccine and 7 serological diagnosis test development. We analysed 2363 sequences of the Spike 8 protein from SARS-CoV-2 isolates and identified variability in 44 amino acid 9 residues and their worldwide distribution in all continents. We use the three-10 dimensional structure of the homo-trimer model for epitope predictions of B-cell, 11 T-Cytotoxic and T-Helper cells. A total of 45 epitopes with amino acids variation 12 were identified. Finally, we show the distribution of mutations within the 13 epitopes. Our findings can help researches to identify more efficient strategies for 14 the development of vaccines, therapies and serological diagnostic tests based on 15 the Spike protein of Sars-Cov-2.16

SARS-CoV-2 mutations and where to find them: An in silico perspective of structural changes and antigenicity of the Spike proteinThe recent emergence of a novel coronavirus (SARS-CoV-2) is causing a severe global health threat characterized by severe acute respiratory syndrome . At the moment, there is no specific treatment for this disease, and vaccines are still under development. The structural protein Spike is essential for virus infection and has been used as the main target for vaccine and serological diagnosis test development. We analysed 2363 sequences of the Spike protein from SARS-CoV-2 isolates and identified variability in 44 amino acid residues and their worldwide distribution in all continents. We used the three-dimensional structure of the homo-trimer model to predict conformational epitopes of B-cell, and sequence of Spike protein Wuhan-Hu-1 to predict linear epitopes of T-Cytotoxic and T-Helper cells. We identified 45 epitopes with amino acid variations. Finally, we showed the distribution of mutations within the epitopes.Our findings can help researches to identify more efficient strategies for the development of vaccines, therapies, and serological diagnostic tests based on the Spike protein of Sars-Cov-2.

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