Candida albicans merupakan jamur oportunistik yang dapat menyebabkan kandidiasis rongga mulut. Insiden kandidiasis rongga mulut karena mikroba dilaporkan 20% -75%. Penggunaan tanaman sebagai obat masih banyak dipakai oleh masyarakat dalam mengatasi berbagai jenis penyakit salah satunya adalah buah pinang tua (Areca catechu L). Tujuan penelitian ini adalah untuk mengetahui aktivitas antijamur ekstrak buah pinang tua (Areca catechu L) terhadap jamur Candida albicans pada pasien kandidiasis rongga mulut. Jenis penelitian yang digunakan adalah eksperimental laboratorium dengan metode disc diffusion. Konsentrasi ekstrak buah pinang tua yang digunakan adalah 5%, 15%, 30%, 45% dan 60%. Analisa data menggunakan uji one way anova. Hasil penelitian diperoleh rata- rata zona hambat berturut-turut konsentrasi 5,8 mm, 9,8 mm, 12,3 mm, 13,2 mm dan 10,5mm. Rata-rata diameter zona hambat paling besar adalah pada konsentrasi 45%. Berdasarkan hasil penelitian disimpulkan bahwa terdapat aktivitas antijamur ekstrak buah pinang tua terhadap daya hambat pertumbuhan jamur Candida albicans.
Background: Periodontal disease is preceded by an inflammation in the gingiva surrounding the teeth called gingivitis. It is an untreated gingivitis causing hard tissue damage (alveolarbone). This inflammation increases the activity of ALP enzyme. Zinc is an Alkaline Phosphatase co-factor. Aim: This study aims at proving the connection between Alkaline Phosphatase (ALP) and zinc within the food of the Minangkabau people in West Sumatra, Indonesia. 60 samples are involved in this study. ALP level is tested by using ELISA technique. Zinc level in Minangkabau food is measured by Food Frequency Questionnaire (FFQ). Data is analyzed by means of univariate to describe each variable , Kolmogorov Smirn of Test is used to see the normal distribution ( p > 0.05). Result: Pearson correlation is conducted to see the correlation between ALP level and zinc clevel in Minangkabau food. The study reveals that ALP activity is higher in mild periodontitis compared to mild gingivitis and healthy control. Zinc level is significantly lower in mild periodontitisthanin mild gingivitis and healthy control individuals. The relation between ALP and zinc level indicates strong correlation with positive direction (r = -0,884). Conclusion: Zn decreases ALP activity and shows that zinc complement has both preventive and curing effects in periodontitis patients.
Introduction:The source of bioactive compounds believed to have strong anticancer potency is derived from sea cucumber. Black sea cucumber (Holothuria atra) is a dominant species in Mentawai Islands, West Sumatera, Indonesia. Key factor compound that acts as anticancer in sea cucumber extract is tritepenoid also known as Frondoside A. The purpose of this study was to determine the effectiveness of the active compound taken from black sea cucumber as anticancer. Methods: Methods used was experimental laboratory. Anticancer activity of black sea cucumber was determined by using the MTT assay cytotoxic test to measure the IC 50 . Cytotoxic test was conducted with Supris clone-1 (SP-C1) derived from cloned lymphadenopathy of patients with oral squamous cell carcinoma on lingual part. Results: It was found that the compounds contained in black sea cucumber has strong anticancer activity (IC50 = 5.25 μL/mL) against SP-C1. Conclusion: Black sea cucumber extract has strong cytotoxic effects against cancer cells SP-C1, therefore black sea cucumber extract potentially developed as a new source of cancer medicine.
Kabupaten Kepulauan Mentawai Provinsi Sumatera Barat mempunyai wilayah pantai yang cukup luas dan tersimpan kekayaan laut yang memiliki potensi ekonomi yang tinggi, salah satunya adalah Teripang. Teripang selain memiliki nilai gizi yang tinggi juga mempunyai aktivitas antibakteri terhadap bakteri patogen. Di bidang kedokteran gigi, Streptococcus viridans merupakan salah satu bakteri penyebab utama dalam permasalahan kesehatan gigi di rongga mulut. Bakteri ini merupakan flora normal di rongga mulut yang dapat menyebabkan karies gigi. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak Teripang Gamat (Stichopus variegatus) dari Kepulauan Mentawai terhadap bakteri Streptococcus viridans. Penelitian ini merupakan penelitian eksperimental laboratorium menggunakan metode disc diffusion (tes Kirby & Bauer) yang telah dilakukan pada bulan Januari-Maret 2016 di Laboratorium Biota Sumatera, Universitas Andalas. Hasil penelitian diuji menggunakan Uji ANOVA dengan tingkat signifikan 5% dengan aplikasi SPSS for windows 16.0. Hasil penelitian diketahui rata-rata diameter zona hambat ekstrak Teripang Gamat (Stichopus variegatus) dari Kepulauan Mentawai terhadap bakteri Streptococcus viridans paling tinggi pada konsentrasi 2,5% dengan nilai 8,45 mm yang termasuk kategori sedang. Nilai p-value dari hasil tes uji anova p-value
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