Anticancer potency of black sea cucumber (Holothuria atra) from Mentawai Islands, Indonesia

Satari, Mieke Hemiawati; Arma, Utmi; Handayani, Dian

doi:10.24198/pjd.vol29no1.11654

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Black sea pepper seems to exaggerate chronic cough [16] instead of alleviating it, although Largus does not state which species of pepper he would use. The potential anticancer effect of black sea peper may justify its use against lymphadenopathy, however, this must have been masking the symptoms of neoplastic diseases rather than helping manage them [17].…”

Section: Nutraceuticals In Ancient Rome: Clinical Practice and Implic...mentioning

confidence: 99%

Nutraceuticals in the Work of Scribonius Largus, a Pioneer of Clinical Pharmacy in Ancient Rome

Tsagkaris¹,

Matiashova²,

Papazoglou³

et al. 2022

IGJPS

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The therapeutic potential of nutraceuticals has been recognized by severalancient civilizations. The majority of physicians would use them in their practice and transmit their experience to their disciples. Nonetheless, few physicians have contributed to the dissemination of this knowledge further and its integration intothe standard of care of their era. Scribonius Largus, a renowned physician and pharmacist in ancient Rome has summarized the existing knowledge on nutraceuticals in his pharmacognosy and therapeutics textbook “Compositiones”. As a physician to the imperial court, he used his position and resources to advance the relevant knowledge, educate erudite and lay physicians across the Roman Empire,and establish ethical practices in the field. Revisiting his contributions provides valuable lessons for contemporary researchers and practitioners.©2022iGlobal Research and PublishingFoundation. All rights reserved.

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Section: Nutraceuticals In Ancient Rome: Clinical Practice and Implic...mentioning

confidence: 99%

Nutraceuticals in the Work of Scribonius Largus, a Pioneer of Clinical Pharmacy in Ancient Rome

Tsagkaris¹,

Matiashova²,

Papazoglou³

et al. 2022

IGJPS

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“…This sea cucumber had the highest cytotoxicity among 15 species of sea cucumbers collected from Gorontalo, Indonesia [8]. In addition, ethanolic extract of H. atra has potential cytotoxicity against several cancer cell lines, namely T47D, HeLa, WiDr [9], HepG2 [10], SP-C1 [11], A549, and B16F10 [12]. Ethanol extract of H. atra could induce apoptosis and activate caspase-3 in T47D cells [13].…”

Section: Introductionmentioning

confidence: 97%

Subchronic Toxicity of Holothuria Atra Ethanol Extract for 90 Days in Histopathology of the Liver and Kidney of Rats

Nursid¹

2023

FARMACIA

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This study aimed to determine the effects of sea cucumber extract Holothuria atra on the histopathology of the liver and kidney of Sprague Dawley rats after 90 days of oral administration. The ethanol extract of H. atra was used. The rats were divided into six groups according to the dose of extract given, namely Group A (control), Group B (dose of 25 mg/kg BW), Group C (dose of 50 mg/kg BW), Group D (dose 100 mg/kg BW), Group E (dose of 200 mg/kg BW), and Group F (dose of 400 mg/kg BW). The extract was administered orally to the rats for 90 days, after which liver and kidney histopathological observations were carried out. The study showed that the administration of H. atra extract to rats caused liver and kidney histopathological changes, especially at 200 mg (group E) and 400 mg (group F). Based on the histopathological description, H. atra extract was toxic to the liver and kidney at 200 mg/kg BW and 400 mg/kg BW. The safe doses of H. atra extract in the liver and kidney were 25 -100 mg/kg BW. The results also showed that the extract with doses of 50 and 100 mg/kg BW positively affected the liver. Holothuria atra extract was toxic to the liver and kidney at 200 mg/kg BW and 400 mg/kg BW; thus, the recommended safe doses are 25 -100 mg/kg BW. RezumatPrezentul studiu a avut ca scop evaluarea efectelor extractului etanolic de castravete de mare (Holothuria atra) asupra modificărilor histopatologice la nivelul ficatului și rinichilor de șobolani Sprague Dawley, după 90 de zile de administrare orală. Șobolanii au fost împărțiți în șase grupuri în funcție de doza de extract administrată, și anume grupul A (martor), grupul B (doza de 25 mg/kg corp), grupul C (doza de 50 mg/kg corp), grupul D (doza de 100 mg/kg corp), grupul E ( doza de 200 mg/kg corp) și grupul F (doza de 400 mg/kg corp). După 90 de zile de administrare orală a extractului, s-a efectuat analiza histopatologică a ficatului și rinichilor. Pe baza analizei histopatologice, extractul de H. atra s-a dovedit toxic pentru ficat și rinichi la 200 mg/kg corp și 400 mg/kg corp, în timp ce dozele sigure recomandate au fost de 25 -100 mg/kg corp.

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“…So far, around 150 types of saponins have been identified from sea cucumbers of class Holothuroidea (Honey-Escandón et al, 2015). Results of previous studies reported that the sea cucumber Holothuria atra had promising cytotoxicity against several cancer cell lines, namely human breast ductal carcinoma (T47D), human cervix epitheloid carcinoma (HeLa), human colon adenocarcinoma (WiDr), human Caucasian hepatocyte carcinoma (HepG2), and human oral tongue squamous cell carcinoma (SP-C1) (Satari et al, 2017;Halimatushadyah et al, 2018). Furthermore, the ethanolic extract of H. atra showed induction of apoptosis and caspase-3 activation in T47D breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Comparison of metabolite profiles and cytotoxicity of the black sea cucumber (Holothuria atra) dried with different drying techniques

Nursid¹,

Patantis²,

Oktavia³

et al. 2022

IFRJ

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Holothuria atra is a species of sea cucumber that could be a source of cytotoxic compounds. The present work aimed to determine the effect of different drying techniques on the profile of metabolites and cytotoxicity of sea cucumber extracts. Sea cucumbers were dried in the sun for 3 d, and then oven-dried at a temperature of 40, 50, and 60°C for 24 h. Fresh sea cucumbers without drying served as a control. The dried and fresh sea cucumbers were extracted by maceration for 12 h using ethanol. The metabolite profiling was performed using Fourier-transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC) analyses, whereas the cytotoxicity was assayed by MTT method using the human breast ductal carcinoma cells (T47D). Analyses of FTIR and HPLC showed that the bioactive compounds of the ethanol extract were relatively stable during drying. This was in line with its cytotoxicity against T47D cells, which did not show significant differences between treatments. Based on these results, it was concluded that drying by sun or oven did not damage the bioactive compounds in the ethanolic extract of sea cucumber.

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Anticancer potency of black sea cucumber (Holothuria atra) from Mentawai Islands, Indonesia

Cited by 5 publications

References 4 publications

Nutraceuticals in the Work of Scribonius Largus, a Pioneer of Clinical Pharmacy in Ancient Rome

Nutraceuticals in the Work of Scribonius Largus, a Pioneer of Clinical Pharmacy in Ancient Rome

Subchronic Toxicity of Holothuria Atra Ethanol Extract for 90 Days in Histopathology of the Liver and Kidney of Rats

Comparison of metabolite profiles and cytotoxicity of the black sea cucumber (Holothuria atra) dried with different drying techniques

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