Objective : to estimate the resistance prevalence of P. aeruginosa to antipseudomonal antibiotics and reveal metallo-beta-lactamases producers among carbapenem resistant clinical isolates. Materials and methods. The subject of the study is clinical isolates of P. aeruginosa resistant to antibacterial drugs. The resistance of P. aeruginosa clinical isolates to antipseudomonal antibiotics was estimated, antimicrobial resistance phenotypes and associated resistance variants were analyzed, and production of metallo-beta-lactamases was detected using phenotypical screening method. Results. High levels of P. aeruginosa resistance to the most of antibacterial drugs, except carbapenems, were revealed. The local features of antimicrobial resistance in different hospitals were established. A total of 19 metallo-beta-lactamase producers were isolated in 6 hospitals of three republican regions. All metallo-beta-lactamase producers have the same phenotype, indicating of clonal prevalence. No carbapenem resistant isolates was resistant to colistin. Conclusion. It is necessary to carry out multi-facet research aimed at the detection of carbapenem resistance mechanisms and epidemiological marking of resistant isolates in order to reveal epidemically significant P.aeruginosa metallo-beta-lactamase producing clones in time and to develop the infection control measures to restrain its circulation.

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The analysis of quantitative and qualitative structure of microflora of a abdominal cavity of patients with a acute and chronic cholecystitis (n = 40) is executed. It is revealed, that the following macroscopical attributes, revealed at the beginning of the operation, statistically significantly (р < 0,001) testify about plenty of pathogenic microorganisms in a abdominal cavity: the expressed destructive changes of a gall-bladder; presence of fibrin in any departments of a abdominal cavity; hyperemia of parietal peritoneum, extending on some anatomic areas or area simultaneous interventions; a plenty of transparent effusion or its muddy character.

The results of 126 bacteriological investigations performed at the Department of vascular surgery, Gomel Regional Cardiologic Dispensary in the period from 2006 to 2007 have been analysed. In all the groups of the examined patients Staphylococcus aureus was the most widespread (33,3-66,7 %) infectious agent. Pseudomonas aeruginosa was most common for the patients suffering from PAD and postphlebitic syndrome (15,4 and 19,3 %, correspondingly) and significantly less prevalent in the group with trophic lesions in varix dilatation (4,8 %). Streptococcus epidermidis was most often revealed in the patients with PAD and varix dilatation (7,7 and 10,5 % correspondingly), аnd Staphylococcus saprophyticus - in the patients with PAD (11,5 %). The carried out analysis provides the ground to consider the application of ciprofloxacin and gentamicin in the initial treatment for all the above listed diseases as the most reasonable.