Objective. To study the peculiarities of antibiotics accumulation in appendix vermiformis after various methods of their introduction. Materials and methods. The investigation was conducted in 160 patients, to whom antibiotic was introduced by various methods: 53 – intramuscularly; 52 – intravenously; 55 – lymphotropically. In part of the patients the antibiotic was introduced at 1 h preoperatively, and to the rest – at 2 h. After performance of appendectomy from each third part of the appendix vermiformis (proximal, middle and distal) excised a homogenate was made, which was sowed into Petri dish on the laboratory culture of E. coli. In a day there were stunting growth zones registered in this laboratory culture in millimeters, and in accordance to their dimensions the level of the antibiotic accumulation was determined. Results. After intramuscular introduction the antibacterial preparation in tissues of appendix vermiformis did not accumulate. After intravenous introduction of ceftriaxone at 1 h preoperatively it have accumulated in 65.4% patients in proximal and middle thirds of appendix vermiformis, in 34.6% patients in the appendix vermiformis apex the antibiotic accumulation was not observed. After the antibiotic introduction 2 h preoperatively its concentration have diminished in two times. After lymphotropic introduction the antibiotic have accumulated in all parts of appendix vermiformis, and in 2 h its quantity have enhanced significantly. Conclusion. Accumulation of antibiotic in the appendix vermiformis after it intravenous introduction have rapidly reduced, and after a lymphotropic one – enhanced, witnessing the advantage of lymphotropic method, which must become the alternative one in appendicitis, due to its targeticity and property for accumulation.

The paper presents the results of research influence of composition on structural-phase state and magnetoresistive properties of as-deposited and heat-treated at temperatures Ta ≤ 900К samples film alloys based on Py and Cu. Samples of thin film alloys with a thickness of d  25 nm in the range of 19 ≤ cCu ≤ 69 (where cCu is the concentration of Cu, at.%) were obtained by the method of co-evaporation in vacuum from two independent evaporators. The structural-phase state of the samples of film alloys at cCu  19 at.%, 34 at.% and 61 at.% was investigated by the method of transmission electron microscopy. The structure of thin films in both as-deposited and annealed at Ta ≤ 900 K state consists of quasi granules with permalloy embedded in a nonmagnetic Cu matrix. The phase state of the samples at cCu  19 at.% and cCu  34 at.% in the as-deposited state and after heat treatment at Ta  600 K corresponded to fcc-NixFe (x ≈ 3) + fcc-Cu. After heat treatment at temperatures of 700  Ta  900 К, the phase state of the samples at cCu  19 at.% and cCu  34 at.% corresponded to Ni3Fe + fcc-Cu. For the film alloy sample at cCu  61 at.% in the as-deposited state and after heat treatment at temperatures of 600  Ta  900 К, the phase state corresponded to fcc-NixFe (x ≈ 3) + fcc-Cu. Studies of the magnetoresistive properties of film samples showed that the film samples in the entire range of compositions of 19 ≤ cCu ≤ 69 at.% were characterized by isotropic magnetoresistance. The maximum value of the giant magnetoresistance was observed for the sample with cCu  34 at.% Both in the as-deposited state and after heat treatment at temperatures of 600  Ta  900 К. Heat treatment of samples in the temperature range of 600  Ta  900 К had almost no effect on the value of GMR films at 19 ≤ cCu ≤ 51 at.%.

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Objective.To compare clinical results of application of lymphotropic antibacterial therapy (LATH) versus standard method of parenteral administration of antibiotics in patients, suffering an acute pancreatitis. Materials and methods. Clinical data, the values of the leucocyte and hematological intoxication indices, and some other indices of immunity, occurring on background of lymphotropic and standard antibacterial therapy, were studied. The patients were distributed into two groups: Group I (the main) - to whom lymphotropic antibioticotherapy was conducted, and Group II (a control one) - to whom a standard antibioticotherapy was applied. Results. In patients of the main group the pain syndrome, belching and regurgitation have had regressed during 2 days of treatment. During 5 days of treatment the intoxication signs have been eliminated. In the patients, admitted to hospital in the first day of an acute pancreatitis manifestation, the values of the intoxication leucocytes index after 5 days of the LATH conduction were on the level of corresponding index of practically healthy people, the CD3 and CD4 quantity raised statistically significantly, and the dimensions of the inflammatory changed pancreatic gland reduced. Conclusion. Lymphotropic injection of antibiotics and anti-inflammatory medicines promotes inhibition of inflammatory process in pancreatic gland. On background of adverse development of inflammation, a more rapid improvement of clinical symptoms of an acute pancreatitis, as well as in the indices of the common markers of inflammatory process and cellular immune defense, are observed. The data obtained witness the advantage of LATH over a standard (parenteral) one in the treatment of an acute pancreatitis.

Objective. To study peculiarities of course and diagnosis of traumatic and spontaneous injuries of ductus thoracicus. Маterials and methods. Ten patients, suffering chylothorax, were observed and examined, using thoracoscopy, аnd exudate - using test with sudan ІІІ. Results. In 6 patients the injuries of ductus thoracicus were revealed: in 1 patient - direct, in 1 - iatrogenic, and in 4 - spontaneous. In 4 patients chylothorax presented a symptom of other diseases. Conclusion. Diagnostic-treatment tactics, if the ductus thoracic injury and presence of chylothorax are suspected, ought to be following: analysis of anamnesis - pleural puncture - exudate aspiration - investigation, directed on identification of the malignant tumor cells and mycobacteria of tuberculosis - test with sudan ІІІ - thoracoscopy - pleurobiopsy - histological investigation - final diagnosis - specialized treatment (оperative-conservative).