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Our results suggest that the combination of STR and MLPA could be a rapid, reliable, and affordable detection protocol for determination of the carrier's status and prenatal diagnosis of DMD in a developing country such as Vietnam.

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This paper presents a method for all-digital background calibration of multiple channel mismatches including offset, gain and timing mismatches in time-interleaved analog to digital converters (TIADCs). The averaging technique is used to remove the offset mismatch at each channel. The gain mismatch is calibrated by calculating the power ratio of the sub-ADC over the reference ADC. Timing skew is compensated by using Hadamard transform for error correction and least mean squares (LMS) algorithm for estimation of the clock skew. The performance improvement of TIADCs employing these techniques is demonstrated through numerical simulations.

The time-interleaved analog-to-digital converters (TIADCs), performance is seriously affected by channel mismatches, especially for the applications in the next-generation communication systems. This work presents an improved all-digital background calibration technique for TIADCs by combining the Hadamard transform for calibrating gain and timing mismatches and averaging for offset mismatch cancellation. The numerical simulation results show that the proposed calibration technique completely suppresses the spurious images due to the channel mismatches at the output spectrum, which increases the spurious-free dynamic range (SFDR) and signal-to-noise and distortion ratio (SNDR) by 74 dB and 43.7 dB, respectively. Furthermore, the hardware co-simulation on the field programmable gate array (FPGA) platform is performed to confirm the effectiveness of the proposed calibration technique. The simulation and experimental results clarify the improvement of the proposed calibration technique in the TIADC’s performance.