Background: The term tanatophorik comes from the Greek word thanatophorus which means "innate death" or "bearing death". The problem that underlies this disease is the process of bone formation. This disease is associated with an autosomal dominant inherited mutation of the fibroblast growth factor 3 receptor (FGFR3) gene on the arm of chromosome 4 (4p16.3). Because FGFR3 is the main modulator in bone formation, the typical clinical features of this disease include shortening of the extremities, curved femur, clover-like skull and narrowing of the thoracic cavity.Tanatophoric dysplasia is a skeletal disorder that is "lethal" or deadly. The deaths occurred due to respiratory failure caused by reduced chest cavity capacity, hypoplastic lungs and / or brainstem compression.Destination: Reported a case of thanatophoric dysplasiaMethod: Case Report Case Report: Case 33 years old woman, with preterm parturient G1P0A0H0 35-36 weeks 1 latent phase + history of 2x laparotomy + suspected fetal tanatophoric dysplasia. On ultrasound examination, it was found that BPD = 9.14 cm; AC = 30.56 cm; HC = 32.05 cm; FL = 2.55 cm; AFI; 9.06cm; SDAU = 1.72 cm. The presence of frontal bosing, saddle nose and micromilia (proximal, distal, phalanges) was found. The patient was planned for vaginal delivery and the progress of labor was followed. Patients provided informed consent regarding the possibility of fetal death during labor and after birth. During the active phase of the labor process, hypotony uterine innersia occurs and oxytocin drip is performed to accelerate labor. The baby was born male, weight 2175 grams, body length 34 cm and A / S: 1/0. Postmortem physical examination revealed macroscopic findings of tanatophoric dysplasia infants such as hypertelorism, low nasal bridge, cranio-facial disproportion. Narrow chest with protruding abdomen and short, bent limbs.Conclusion: Tanatophoric dysplasia is "lethal" skeletal dysplasia. Careful prenatal examination is required in diagnosis and termination of pregnancy. Keywords: Thanatophoric dysplasia, prenatal diagnosis

AbstrakPosyandu terintegrasi Pendidikan Anak Usia Dini (PAUD) merupakan penyelenggaraan integrasi layanan sosial dasar di posyandu, salah satunya adalah pembinaan gizi dan kesehatan ibu anak serta pos PAUD. Posyandu yang melaksanakan program pengembangan tambahan, meliputi perkembangan kognitif, bahasa, fisik, sosial dan emosional anak yang dapat dipantau salah satunya pada integrasi Posyandu PAUD, namun pelaksanaannya belum maksimal. Tujuan: Menentukan hubungan kunjungan posyandu terintegrasi PAUD dengan status gizi dan kemampuan berbahasa pada anak balita usia 4-5 tahun. Metode: Desain penelitian yaitu crossectional terhadap 73 responden. Pengumpulan data dilakukan dengan melakukan observasi langsung pada anak menggunakan lembar pedoman perkembangan bahasa anak di Posyandu terintegrasi PAUD pada bulan Maret sampai September 2019 dengan metode simple random sampling menggunakan uji Chi-square. Hasil: Analisis kuantitatif menunjukkan bahwa lebih dari separoh kunjungan posyandu terintegrasi PAUD tidak aktif (60,2%), sebagian besar status gizi lebih (68,5%), lebih dari separoh kemampuan berbahasa anak kurang baik (60,2%). Hasil uji Chi-Square menunjukkan terdapat hubungan kunjungan posyandu terintegrasi PAUD dengan status gizi (ρ<0,05) dan kemampuan berbahasa (ρ<0,05) anak balita usia 4-5 tahun. Simpulan: Kunjungan posyandu terintegrasi PAUD penting dihadiri oleh ibu untuk memantau status gizi dan kemampuan berbahasa anak.

Background: One of the important problems in obstetrics is premature rupture of membranes. Incidence of premature rupture of membranes caused by multifactorial, including the factors of infection and nutrients of pregnant women that affect the elasticity of membranes. The aim of the study to investigate the relationship vitamin C level and MMP-2 serum with premature rupture of membranes and normal pregnancy. Methods: This research is cross sectional comparative study design. The research is in the Midwife Room of Bhayangkara Hospital, dr. Reksodiwiryo and dr. Rasidin Hospital Padang in September-October 2017. The population in this study were pregnant women with early rupture of membranes and all women with normal pregnancy (gestational age ≥ 37-42 weeks) and sample size 58 people in two groups. Sampling technique with consecutive sampling. The examination of vitamin C and MMP-2 levels was performed in Biomedical Laboratory of Faculty of Medicine, Universitas Andalas by ELISA method. Test of data normality with Shapiro-Wilk test and independent sample T test and Pearson correlation for hyphotesis. Results: The results showed that mean of vitamin C level in premature rupture of membranes was 0.53 ± 0.09 mg/dl, and 0.58 ± 0.08 mg/dl in normal pregnancy (p <0.05). The mean of MMP-2 level in premature rupture of membranes was 35.17 ± 2.23 ng/ml, and 33.27 ± 0.82 ng/ml in normal pregnancy (p <0.05). There was no relationship between vitamin C and MMP-2 levels with premature rupture of membranes and normal pregnancy (p> 0.05). Conclusion: The conclusion of this study there were mean difference of vitamin C and MMP-2 levels in premature rupture of membranes and normal pregnancy. However, there was no relationship between vitamin C and MMP-2 levels in premature rupture of membranes and normal pregnancy Index Terms-MMP-2, premature rupture of membranes, vitamin C.

AbstrakAngka Kematian Ibu (AKI) masih cukup tinggi di Indonesia, karena disebabkan oleh perdarahan, eklamsi dan infeksi. American College of Obstetricans and Gynecologist merekomendasikan senam selama kehamilan agar persalinan lancar dan mengurangi komplikasi saat persalinan. Tujuan penelitian adalah menentukan perbedaan antara jumlah perdarahan saat persalinan pada Ibu primigravida yang melakukan dan tidak melakukan senam hamil selama kehamilan trimester III. Jenis penelitian adalah rancangan comparative study. Penelitian dilaksanakan di wilayah kerja Puskesmas Andalas dan Lubuk Buaya dari Oktober 2018 sampai Januari 2019. Jumlah sampel adalah 44 orang di bagi menjadi 2 kelompok, yaitu pertama 22 orang ibu yang melakukan senam hamil dan 22 orang ibu yang tidak melakukan senam hamil. Pengambilan sampel dengan consecutive sampling. Analisis data menggunakan system komputerisasi dengan uji independent t-test. Hasil penelitian didapatkan rerata jumlah perdarahan pada ibu yang senam hamil 489,18 cc dan pada ibu yang tidak senam hamil 501,86 cc. Tidak terdapat perbedaan jumlah perdarahan pada ibu yang melakukan dan tidak melakukan senam hamil dengan nilai (p=0,786). Kata kunci: jumlah perdarahan, senam hamil, primigravida AbstractThe maternal mortality rate is high in Indonesia, that is caused by bleeding, eclampsia and infection. The American College of Obstetricans and Gynecologists recommend gymnastics during pregnancy so that labor is smooth and reduces complications during labor. The objective of the study was to determine the differences number of bleeding at delivery between primigravida who did pregnancy exercise and did not during the third trimester of pregnancy.The type of this research was a comparative study design. The study was conducted in the working area of Andalas and Lubuk Buaya Puskesmas from October 2018 until January 2019. The number of samples were forty four people, divided into two groups; twenty two mothers who did pregnancy exercises and twenty two mothers who did not do pregnancy exercises. Sampling by consecutive sampling. Data analysis using a computerized system with independent t-test.The average number of bleeding in mothers who exercise 489.18 cc and mothers who are not pregnant exercise 501.86 cc. There is no difference in the number of bleeding (p = 0.786).

Status gizi memiliki pengaruh yang signifikan terhadap tumbuh kembang anak. Gizi yang kurang baik selama 1000 hari pertama kehidupan (HPK) dapat menurunkan risiko terkena penyakit, salah satunya adalah stunting, begitu juga risiko kematian yaitu sekitar 13%. Tahun 2018 persentase balita sangat pendek dan pendek usia 0-59 bulan adalah 11,5% dan 19,3%. Besarnya risiko stunting terhadap bayi dan balita, maka perlu diadakannya deteksi dini stunting tersebut sebagai salah satu upaya untuk membantu meningkatkan pengetahuan yang berimplementasi terhadap kegiatan pemantauan pertumbuhan dan perkembangan bayi dan balita yag lebih optimal. Kegiatan telah dilaksanakan terhadap ibu yang memiliki bayi dan balita sebanyak 20 orang. Metode kegiatan berupa penyuluhan, pemeriksaan fisik dan deteksi dini tumbuh kembang dengan kuisioner KPSP. Hasil kegiatan diperoleh bahwa 6,25% bayi kurus dan 6,25% bayi obesitas, 44% bayi dan balita kategori pendek, 6% sangat pendek, 81% ASI Eksklusif, 6% bayi dengan penyimpangan (gerak halus, sosialisasi dan kemandirian) dan 6% hasil meragukan (gerak kasar). Diharapkan kepada suami, keluarga dan masyarakat melakukan pemantauan pertumbuhan dan perkembangan bayi dan balita untuk mencegah stunting dan gangguan pertumbuhan dan perkembangan lainnya. Petugas kesehatan agar selalu menggalakkan program nutrisi seimbang dan upaya pencegahan stunting lainnya sejak masa persiapan kehamilan (prakonsepsi).