Trapa natans L., water chestnut (indian name singada, montenegrin name kasaronja) belonging to Trapaceae family is annual aquatic floating herb native to Asia but widely distributed in the Europe and in North America. The presence of two species, Trapa natans L. and Trapa longicarpa M.Jank. ssp. scutarensis M.Jank has been confirmed on the Skadar lake in Montenegro. Trapa natans is a plant demonstrating promising pharmacological activity mostly due to the presence of its constituens, phenols and flavonoids, showed hepatoprotective potential, antioxidant, anti-inflammatory, antidiabetic, antifungal and in vitro antimicrobial activity.

Background: Benzodiazepines can be classified as one of the most frequently prescribed categories of medication. This medication category is distinguished by a high risk of tolerance and dependence, in the case of long-term, excessive use. Aim: The aim of our study was to analyse the use of benzodiazepines in the general population, municipality of Berane, Montenegro, during the previous year. Methods: Research was based on the analysis of 1000 prescriptions of benzodiazepines, issued by physicians in Primary Health Care. The diagnostic manual utilised for the purpose of this research was International Classification of Diseases (ICD-10). The survey was conducted for a period of 40 days during January and February 2015. Results: The study was performed in the general population, age from 18 to 98 years (621 females and 379 males). The average age of all participants in the study was 64.1±13.1 years. Analysis of data confirmed that the most frequently prescribed from the group of benzodiazepines were: diazepam (42.2%), bromazepam (30.3%), lorazepam (16.4%), alprazolam (6.4%), nitrazepam (2.6%) and clonazepam (2.1%). The significant statistical difference (χ²=58.664; p<0.001) was found between female patients who used benzodiazepines in 62.1% of cases, compared to male patients who used benzodiazepines in 37.9% of cases. It was confirmed that benzodiazepines were usually prescribed for 17 different diagnoses, mostly for diagnoses from the group I, viz. cluster-diseases of the circulatory system (39.7%), group F-mental and behavioural disorders (31.1%) and group E-endocrine, nutritional and metabolic diseases (7.7%). Conclusion: Studies about drug utilisation provide plenty of useful information which can be further used with the aim of achieving more rational prescribing and more effective patient treating.

Dutasteride is a cost effective option for treating BPH comparing to finasteride. The results of this study provide new information for health care decision makers about treatment of BPH in socioeconomic environment which is actual both in Montenegro and other countries with a recent history of socioeconomic transition.

Bevacizumab neutralizes a key stimulation factor in tumour angiogenesis -vascular endothelial growth factor (VEGF). Th e origin of VEGF is related to platelets, and the basic stimulus for its production is hypoxia. By neutralizing VEGF, changes occur in the blood that are manifested at the platelet and haemoglobin levels. Study results indicate that proteinuria is

АТЦ класификација-Анатомско-терапијско-хемијска класификација АУР-Акутно задржавање урина БПХ-Бенигна хиперплазија простате ЦАЛИМС-Агенција за љјекове и медицинска средства Црне Горе ДДД-Дефинисана дневна доза ЕАУ-Европска асоцијација за урологију ФЗО-Фонд за здравствено осигурање Црне Горе ИПСС-Међународни Простата Симптом Резултат ИЈЗЦГ-Институт за јавно здравље Црне Горе