Blastocystis spp pathogenic potential remains controversial. Recently, many researchers have suggested the possible etiological relationship between symptomatic skin rashes and Blastocystic morphological forms, genetic diversity and microbiota interaction. A small observation series of acute and chronic urticaria caused by Blastocystic hominis in elderly patients has been herein presented. These cases emphasize the importance of adequate parasite verification under appropriate clinical settings and upon elimination of other more common causative factors as well as the significance of proper etiological treatment in urticaria patients.

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Rowell syndrome is a rare skin disease described as an association of erythema multiforme and systemic lupus erythematosus, immunologically characterized by speckled antinuclear, anti-Ro, and anti-La antibodies. The majority of described cases affect middle-aged women. We report a case of a 53-year-old man with no previous history of lupus erythematosus, who developed erythema multiforme-like lesions and immunological findings consistent with Rowell syndome upon an intake of non-steroidal anti-inflammatory drugs. The patient responded well to systemic steroids and hydroxychloroquine. A short overview, emphasizing the specific clinical, laboratory and histology findings of this peculiar syndrome, is also presented.

COVID-19 is an ongoing multisystemic viral infection, which affects both adults and children. The virus has a complicated and not fully understood pathophysiological mechanism of damaging different organs and systems, including the skin. Cutaneous manifestations classification is complicated by the great variety of lesions and histological appearances, neither specific. Herein, a thorough overview of the clinical and pathological peculiarities of skin changes observed in the acute and re-convalescent stages of COVID-19 infection, is highlighted. The pathophysiological mechanisms, suggested to trigger and sustain the dermatological dysfunction, are also considered in the vicinity of authors’ personal experience.

Interstitial granulomatous dermatitis is a rare skin condition that presents with erythematous violaceous plaques mostly associated with pruritus and pain. The etiopathogenesis remains obscure, hence, it is often associated with autoimmune systemic diseases and systemic infections. Herein, we present an anecdotal case of interstitial granulomatous dermatitis in a male patient with immune constellation of systemic lupus erythematosus. A comprehensive review of the literature on the possible pathogenetic pathways and clinical peculiarities is also highlighted.