Introdução: A gestação e o período pós-parto estão associados a diversas alterações fisiológicas que resultam na elevação do risco de eventos tromboembólicos. O tromboembolismo venoso (TEV) representa uma importante causa de morbimortalidade materna e se apresenta por meio de duas entidades clínicas diferentes: embolia pulmonar (EP) e trombose venosa profunda (TVP). A manifestação de sinais e sintomas comuns durante a gravidez associada à limitação do uso de radiação e elevação progressiva normal do D-dímero tornam o diagnóstico da TVP na gestação um desafio. Desenvolvimento: Trata-se de um artigo de revisão a partir de trabalhos selecionados sistematicamente nas bases de dados MEDLINE e LILACS com base nos indexadores: trombose venosa, gravidez e diagnóstico. Considerações finais: A gestação representa um estado pró-trombótico transitório, onde todos os componentes da tríade de Virchow são afetados. Diversos fatores associados ao período gestacional resultam em um padrão epidemiológico e de manifestação clínica distinto da população não gestante. A TVP representa a maioria dos casos de TEV sintomáticos no período pré-parto e acomete predominantemente o sistema venoso proximal. O estado pró-trombótico resulta na elevação dos níveis de D-dímero na gravidez, diminuindo a especificidade do exame. A ultrassonografia compressiva representa o exame de escolha diante da suspeita de TVP na gestação. A investigação diagnóstica possui limitações importantes e necessita de estudos direcionados para o desenvolvimento e aperfeiçoamento de estratégias para o diagnóstico de TVP em gestante.   Palavras-chave: Trombose Venosa; Gravidez; Diagnóstico. ABSTRACT Introduction: Gestation and the postpartum period are associated with several physiological changes that result in an increased risk of thromboembolic events. Venous thromboembolism (VTE) is an important cause of maternal morbidity and mortality and is presented through two different clinical entities: pulmonary embolism (PE) and deep vein thrombosis (DVT). The manifestation of common signs and symptoms during pregnancy associated with limitation in the use of radiatiotn and normal progressive elevation of D-dimer make the diagnosis of DVT during pregnancy challenging. Development: This is a review article based on systematically selected papers in the MEDLINE and LILACS databases based on the indexes: venous thrombosis, pregnancy and diagnosis. Final considerations: Gestation represents a transient prothrombotic state, where all components of the Virchow triad are affected. Several factors associated with the gestational period result in an epidemiological pattern and distinct clinical manifestation of the non-pregnant population. DVT represents the majority of cases of symptomatic VTE in the prepartum period and predominantly affects the proximal venous system. The prothrombotic state results in elevation of D-dimer levels in pregnancy, decreasing the specificity of the test. Compression ultrasonography represents the examination of choice in view of the suspicion of DVT during pregnancy. The diagnostic investigation has important limitations and needs studies directed to the development and improvement of strategies for the diagnosis of DVT in pregnant women. Keywords: Venous Thrombosis; Pregnancy; Diagnosis.

Background: Consumption of crack is one of the major challenges in public health and taking this drug has direct effects on the health of those who use it. Objectives: To evaluate the profile of vascular abnormalities in patients receiving treatment for crack dependency at a Psychosocial Care Center for Alcohol and Drugs and to observe possible peripheral vascular effects. Methods: The study design is observational, descriptive and cross-sectional. An objective questionnaire was administered to the patients in the sample to collect data on demographic details; drug use profile; and concomitant diabetes mellitus, arterial hypertension and/or smoking; and physical and ultrasound examinations were conducted. Data were summarized and analyzed statistically with the chi-square test or Fisher' s exact test. Results: The mean age of the sample was 33.29 (±7.15) years, and 74% were male. Mean age at onset of drug use was 23.4 (±7.78) years and mean time since onset was 9.58 (±5.64) years. Mean consumption of crack rocks was 21.45 (±8.32) per day. The rate of abnormal lower limb pulses was higher among women. The prevalence of artery wall thickening in lower limbs was 94.8%. Time since starting to use crack exhibited a statistically significant association (p = 0.0096) with abnormalities in the spectral curve profiles of lower limb arteries. Conclusions: Crack users exhibit peripheral vascular disorders. Length of time since starting to use the drug had the greatest impact on this system, suggesting an association between crack use and reduced arterial flow.