Significant improvement in the hepatic histology of steatosis was observed after weight loss induced by bariatric surgery in most patients. There was no patient with a worsening in the histology.

High expression levels of survivin in the primary tumor may be used as a potential predictive biomarker of pCR to neoadjuvant chemotherapy in patients with stage II and stage III breast cancer.

Introduction. The Cancer Genome Atlas (TCGA) project and Asian Cancer Research Group (ACRG) recently categorized gastric cancer into molecular subtypes. Nevertheless, these classification systems require high cost and sophisticated molecular technologies, preventing their widespread use in the clinic. This study is aimed to generating molecular subtypes of gastric cancer using techniques available in routine diagnostic practice in a series of Moroccan gastric cancer patients. In addition, we assessed the associations between molecular subtypes, clinicopathological features, and prognosis. Methods. Ninety-seven gastric cancer cases were classified according to TCGA, ACRG, and integrated classifications using a panel of four molecular markers (EBV, MSI, E-cadherin, and p53). HER2 status and PD-L1 expression were also evaluated. These markers were analyzed using immunohistochemistry (E-cadherin, p53, HER2, and PD-L1), in situ hybridization (EBV and HER2 equivocal cases), and multiplex PCR (MSI). Results. Our results showed that the subtypes presented distinct clinicopathological features and prognosis. EBV-positive gastric cancers were found exclusively in male patients. The GS (TCGA classification), MSS/EMT (ACRG classification), and E-cadherin aberrant subtype (integrated classification) presented the Lauren diffuse histology enrichment and tended to be diagnosed at a younger age. The MSI subtype was associated with a better overall survival across all classifications (TCGA, ACRG, and integrated classification). The worst prognosis was observed in the EBV subtype (TCGA and integrated classification) and MSS/EMT subtype (ACRG classification). Discussion/Conclusion. We reported a reproducible and affordable gastric cancer subtyping algorithms that can reproduce the recently recognized TCGA, ACRG, and integrated gastric cancer classifications, using techniques available in routine diagnosis. These simplified classifications can be employed not only for molecular classification but also in predicting the prognosis of gastric cancer patients.

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Space exploration is conducted in unique environments, such as on low-Earth orbit platforms, onboard planetary and deep space probes, and operations on the surface of the Moon and the planets (4). The characteristics of these environments and the structures needed to support human life, as well as the difficulties and costs of travel from Earth, make it impossible for medical teams to assist astronauts personally. Therefore, a solution was sought to ensure the welfare of the space travelers.The need for communication in space and between Earth and space set new frontiers for the development of telecommunication technologies and computational systems, encouraging innovative ideas to spread. This rapid process of evolution has promoted amazing modifications in almost all aspects of daily human life (1). One such advance was telemedicine, which involves the use of technological tools for the acquisition, storage and transmission of health data, and enables virtual meetings among professionals located in different parts of a region, country, or even the world (5,6).The diffusion of telecommunication technologies at low cost has made possible the implementation of a wide range of telemedicine systems supporting clinical practices in different regions of the world (7). It has the potential to enable health planning, research, education, clinical discussion, and obtaining second opinions to take place (3).The National Aeronautics and Space Administration (NASA) has been involved in the application of telemedicine since the earliest days of human spaceflight. Telemedicine is critical to the success of missions involving humans and has been an integral part of the health care delivery system for the space program from the beginning (4). This technology has been adapted for Earth-based application and can play an important role in a large country such as Brazil. Many areas of Brazil are remote and difficult to access, with hazardous environments that make it problematic and costly to provide adequate health care to the local populations. This problem can be further compounded by additional complexities such as uneven distribution of financial resources and severe social problems, making improvements in health assistance in remote areas more difficult. This results in delays in the diagnosis, treatment, and adequate management of medical conditions. As was found in space programs, telemedicine, e-health, and computerbased guidelines have proven to be optimal tools for overcoming these circumstances, enabling easier access to remote diagnosis and providing support to clinical decisions.The Microgravity Centre/FENG (Faculty of Engineering) at PUCRS (Pontificia University Catholic of Rio Sul) has developed a telemedicine project with the main aim of making specialized medical assistance available to remote communities, as those found in the Amazon region, using telecommunication systems, mobile technologies, and biomedical engineering as tools. Dermatology and odontology, with the support of pathology, were the medical special...