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Phenol-croton oil peel generates skin neocollagenesis. Combination of 35% phenol and 0.4% to 1.6% croton oil creates formulas that vary in intensity and penetration capacity, being used for different degrees of skin aging and application areas, with low demarcation and systemic risk. 1,2 An open, longitudinal, non-placebo-controlled study was conducted with 30 women (52 to 87 years old; Fitzpatrick I to IV) with moderate-to-severe perioral aging (Scales of Glogau≥III, Baker≥II, and Cohen≥moderate), excluding those with systemic diseases and 12-month-previously perioral esthetic procedure. SPF60 was used for 30 days pre-peeling and acyclovir 400mg, Q4H, for 7 days postpeeling. Forty-mg codeine was administered 1 hour before and maintained BID for 2 days post-procedure.Before (D0) and 90±2days after (D90±2) the procedure, photographs and punch-n 0 4 biopsies were performed (D0, 0.5cm, laterally to the left filtrum midpoint; D90±2, 0.5cm laterally to the D0's).