A series of 4,6-disubstituted 2-(5-nitrofurfurylidenehydrazino)-1,3,5-triazines has been synthesized. Some of these compounds possessed good antibacterial activity against Mycobacterium tuberculosis in vitro and moderate activity in vivo (the activity in vivo was observed only with high dosages compared with compounds in clinical use and the results were also irregular). The most active compounds are triazinylhydrazones of 5-nitro-2-furaldehyde in which the triazine ring is substituted with two amino-groups, at least one of which is an (a-branched chain alky1)-or cycloalkylamine. Structure-antituberculosis activity relations for these compounds are discussed.

No abstract

No abstract

No abstract

No abstract